Reducing impulsive choice: V. The role of timing in delay-exposure training.
Reducing impulsive choice: V. The role of timing in delay-exposure training.
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DOI：
10.1016/j.beproc.2018.04.018
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发表时间：
2018-12
影响因子：
1.3
通讯作者：
Madden GJ
中科院分区：
文献类型：
--
作者：
Rung JM;Buhusi CV;Madden GJ
冲动决策在成瘾相关疾病中很常见，一些研究表明，冲动决策在成瘾相关疾病的发展中起着因果作用。因此，减少冲动决策可以预防或减少与成瘾相关的行为。最近的研究表明，长期经历与反应相关的延迟奖励（延迟暴露[DE]训练）会减少大鼠的冲动选择，但尚不清楚这种效应背后的行为机制是什么。本研究评估了间隔时间的改善是否会介导定向训练对冲动选择的影响。 39 只 Long-Evans 大鼠被随机分配到完成 DE、即时或无暴露训练的组，然后进行冲动选择和计时任务（颞二分）。尽管复制了 DE 对冲动选择的影响，但计时准确性和精确度不受 DE 训练的影响，并且与冲动选择无关。目前的研究结果并没有重复之前的报告，即计时精度和冲动选择是相关的，这可能是由于实验室间冲动选择任务的差异所致。继续研究确定 DE 培训的候选行为机制可能有助于提高培训效果并促进转化工作。
Impulsive decision-making is common in addiction-related disorders, with some research suggesting it plays a causal role in their development. Therefore, reducing impulsive decision-making may prevent or reduce addiction-related behaviors. Recent research shows that prolonged experience with response-contingent delayed reward (delay exposure [DE] training) reduces impulsive choice in rats, but it is unclear what behavioral mechanisms underlie this effect. The present study evaluated whether improvements in interval timing mediate the effects of DE training on impulsive choice. Thirty-nine Long-Evans rats were randomly assigned to groups completing DE, immediacy-, or no-exposure training, followed by impulsive-choice and timing tasks (temporal bisection). Despite replicating the DE effect on impulsive choice, timing accuracy and precision were unaffected by DE training and unrelated to impulsive choice. The present findings did not replicate previous reports that timing precision and impulsive choice are related, which may be due to between-laboratory differences in impulsive choice tasks. Continued research to identify candidate behavioral mechanisms of DE training may assist in improving training efficacy and facilitating translational efforts.
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DOI：
10.1111/add.13535
发表时间：
2017-01
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Amlung M;Vedelago L;Acker J;Balodis I;MacKillop J
通讯作者：
MacKillop J
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
3.4
作者：
MacKillop, James;Amlung, Michael T.;Few, Lauren R.;Ray, Lara A.;Sweet, Lawrence H.;Munafo, Marcus R.
通讯作者：
Munafo, Marcus R.
DOI：
10.1111/add.12283
发表时间：
2013-11
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Fernie G;Peeters M;Gullo MJ;Christiansen P;Cole JC;Sumnall H;Field M
通讯作者：
Field M
影响因子：
6.9
作者：
Amlung, M.;Petker, T.;MacKillop, J.
通讯作者：
MacKillop, J.