Critical role of lipid membranes in polarization and migration of cells: a biophysical view.
Critical role of lipid membranes in polarization and migration of cells: a biophysical view.
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DOI：
10.1007/s12551-021-00781-1
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发表时间：
2021-03
影响因子：
--
通讯作者：
Tanaka M
中科院分区：
文献类型：
--
作者：
Sackmann E;Tanaka M
细胞迁移在许多生物学过程中起着至关重要的作用，如组织形态发生和肿瘤转移等，在过去的几十年里，它引起了生物物理学家的极大兴趣。然而，尽管越来越多的研究强调了参与不同信号通路的蛋白质的协调，但脂膜的功能作用基本上被忽视了。脂膜通常被认为是一种无功能的二维蛋白质基质，尽管许多调节细胞迁移的蛋白质只有在被招募到膜表面并自组织其功能区后才能获得功能。在这篇综述中，我们总结了蛋白质在脂膜中的后勤招募和释放是如何协调复杂的时空分子过程的。根据Smoluchowski扩散方程的经典框架预测，脂质/蛋白质膜作为2D反应中枢，有助于有效而有力地调节细胞的极化和迁移，涉及几个相互竞争的途径。
Cell migration plays vital roles in many biologically relevant processes such as tissue morphogenesis and cancer metastasis, and it has fascinated biophysicists over the past several decades. However, despite an increasing number of studies highlighting the orchestration of proteins involved in different signaling pathways, the functional roles of lipid membranes have been essentially overlooked. Lipid membranes are generally considered to be a functionless two-dimensional matrix of proteins, although many proteins regulating cell migration gain functions only after they are recruited to the membrane surface and self-organize their functional domains. In this review, we summarize how the logistical recruitment and release of proteins to and from lipid membranes coordinates complex spatiotemporal molecular processes. As predicted from the classical framework of the Smoluchowski equation of diffusion, lipid/protein membranes serve as a 2D reaction hub that contributes to the effective and robust regulation of polarization and migration of cells involving several competing pathways.
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影响因子：
64.5
作者：
Fukata, M;Watanabe, T;Kaibuchi, K
通讯作者：
Kaibuchi, K
DOI：
10.1103/physreve.95.012401
发表时间：
2017-01
期刊：
Physical review. E
影响因子：
--
作者：
Camley BA;Zhao Y;Li B;Levine H;Rappel WJ
通讯作者：
Rappel WJ
影响因子：
2
作者：
Giese, Wolfgang;Eigel, Martin;Klipp, Edda
通讯作者：
Klipp, Edda
影响因子：
4.6
作者：
Burk AS;Monzel C;Yoshikawa HY;Wuchter P;Saffrich R;Eckstein V;Tanaka M;Ho AD
通讯作者：
Ho AD
影响因子：
21.3
作者：
通讯作者：
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