Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI.

Evaluation of SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for human fMRI.
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DOI:
10.1016/j.neuroimage.2017.02.001
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发表时间:
2018-01-01
期刊:
影响因子:
5.7
通讯作者:
Feinberg DA
Feinberg DA
中科院分区:
医学1区
文献类型:
--
作者:
Vu AT;Beckett A;Setsompop K;Feinberg DA

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高各向同性分辨率fMRI是具有挑战性的,主要是由于长的重复时间(TR)和不足的SNR,特别是在较低的场强。最近,同步多切片(SMS)成像与blipped-CAIPI大大减少了扫描时间和提高信噪比效率的功能磁共振成像。类似地,利用切片方向上的子体素空间移位的超分辨率技术已经提高了分辨率和SNR效率。在这里,我们证明了协同组合的SLICE抖动增强分辨率(SLIDER)和SMS的高分辨率,高SNR的全脑功能磁共振成像相比,标准分辨率的功能磁共振成像数据,以及高分辨率的数据。使用SLIDER-SMS,即使在没有超分辨率去模糊算法的情况下,也可以恢复(无混叠)高空间频率信息。此外,我们发现,BOLD CNR(以视觉棋盘格范例中的t值测量)相对于传统采集的高分辨率数据提高了100%。在CNR中使用此增益,我们能够在3 T(0.66 mm)和7 T(0.45 mm)下获得前所未有的标称各向同性分辨率。
High isotropic resolution fMRI is challenging primarily due to long repetition times (TR) and insufficient SNR, especially at lower field strengths. Recently, Simultaneous Multi-Slice (SMS) imaging with blipped-CAIPI has substantially reduced scan time and improved SNR efficiency of fMRI. Similarly, super-resolution techniques utilizing sub-voxel spatial shifts in the slice direction have increased both resolution and SNR efficiency. Here we demonstrate the synergistic combination of SLIce Dithered Enhanced Resolution (SLIDER) and SMS for high-resolution, high-SNR whole brain fMRI in comparison to standard resolution fMRI data as well as high-resolution data. With SLIDER-SMS, high spatial frequency information is recovered (unaliased) even in absence of super-resolution deblurring algorithms. Additionally we find that BOLD CNR (as measured by t-value in a visual checkerboard paradigm) is improved by as much as 100% relative to traditionally acquired high-resolution data. Using this gain in CNR, we are able to obtain unprecedented nominally isotropic resolutions at 3T (0.66 mm) and 7T (0.45 mm).
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