The Differential Effect of Toxoplasma Gondii Infection on the Stability of BCL2-Family Members Involves Multiple Activities.
The Differential Effect of Toxoplasma Gondii Infection on the Stability of BCL2-Family Members Involves Multiple Activities.
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弓形虫感染对 BCL2 家族成员稳定性的不同影响涉及多种活动。
DOI：
10.3389/fmicb.2011.00001
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发表时间：
2011
影响因子：
5.2
通讯作者：
Sinai AP
中科院分区：
文献类型：
--
作者：
Carmen JC;Sinai AP
线粒体通透性的调节是启动细胞凋亡的一个关键事件，它由bcl2家族中促凋亡和抗凋亡成员的相反行为所控制。BCL2家族可以根据它们编码的BCL同源(BH)结构域的数量进一步分类。病原体介导的bcl2家族成员的调控在其影响感染宿主细胞中的凋亡途径的能力中起着重要作用。原生动物寄生虫弓形虫建立了一种深刻的凋亡阻断，其特点是需要宿主的NFκB活性，并与促凋亡的bcl2家族成员的选择性降解有关。在这项研究中，我们探索了与抗凋亡bcl2的内在稳定性以及促凋亡蛋白Bax、Bad和Bid的选择性降解相关的潜在活性。我们发现，BCL2家族成员的相对稳定性由多种活动控制，这表明寄生虫感染扰乱了一个复杂而平衡的稳定增强和破坏稳定活动网络。这些数据为寄生虫诱导的宿主活动以及寄生虫效应器在感染过程中控制BCL2蛋白相对水平的直接后果提供了可能性。
The regulation of mitochondrial permeability, a key event in the initiation of apoptosis is governed by the opposing actions of the pro- and anti-apoptotic members of the BCL2-family of proteins. The BCL2-family can be classified further based on the number of BCL-homology (BH) domains they encode. Pathogen mediated modulation of BCL2-family members play a significant role in their ability to affect the apoptotic pathways in the infected host cell. The protozoan parasite Toxoplasma gondii establishes a profound blockade of apoptosis noted by a requirement for host NFκB activity and correlating with the selective degradation of pro-apoptotic BCL2-family members. In this study, we explore the potential activities associated with the inherent stability of the anti-apoptotic BCL2 as well as the selective degradation of the pro-apoptotic proteins BAX, BAD, and BID. We find that multiple activities govern the relative stability of BCL2-family members suggesting a complex and balanced network of stability-enhancing and–destabilizing activities are perturbed by parasite infection. The data leave open the possibility for both parasite induced host activities as well as the direct consequence of parasite effectors in governing the relative levels of BCL2-proteins in the course of infection.
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影响因子：
3.1
作者：
Dong, F;Su, H;Zhong, GM
通讯作者：
Zhong, GM
影响因子：
4.8
作者：
Bradley, PJ;Ward, C;Boothroyd, JC
通讯作者：
Boothroyd, JC
影响因子：
4.3
作者：
Gogvadze, Vladimir;Orrenius, Sten;Zhivotovsky, Boris
通讯作者：
Zhivotovsky, Boris
影响因子：
37.8
作者：
Dechend, R;Maass, M;Gulba, DC
通讯作者：
Gulba, DC
影响因子：
--
作者：
Fox, Barbara A.;Ristuccia, Jessica G.;Bzik, David J.
通讯作者：
Bzik, David J.