Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi: environmental and genetic effects.
Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi: environmental and genetic effects.
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DOI：
10.1111/eva.12005
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发表时间：
2013-02
影响因子：
4.1
通讯作者：
Yates AJ
中科院分区：
文献类型：
--
作者：
Cameron A;Reece SE;Drew DR;Haydon DT;Yates AJ
寄生虫可能会改变它们的行为，以应对宿主内环境的变化。特别是，对传播的投资可能会随着寄生虫资源或宿主免疫反应的可获得性而改变。然而，关于寄生虫对栖息地质量恶化的最佳(适应性)反应，实验和理论研究得出了相互矛盾的结论。我们分析了查鲍迪疟原虫六种基因型鼠疟疾急性感染的数据，以量化宿主内环境对传播(配子体)的投资是如何影响的。使用最少的模型假设，我们发现配子体发生的比例投资随着宿主贫血而急剧增加，并且在低寄生虫密度时也增加。此外，投资对寄生虫密度的依赖性更强，与寄生虫基因的毒力更强相关。我们的研究为研究寄生虫对宿主环境的反应以及这些反应是否具有适应性提供了一个强大的量化框架，这对于预测寄生虫病传播阻断治疗的短期和进化影响至关重要。
Parasites may alter their behaviour to cope with changes in the within-host environment. In particular, investment in transmission may alter in response to the availability of parasite resources or host immune responses. However, experimental and theoretical studies have drawn conflicting conclusions regarding parasites' optimal (adaptive) responses to deterioration in habitat quality. We analyse data from acute infections with six genotypes of the rodent malaria species Plasmodium chabaudi to quantify how investment in transmission (gametocytes) is influenced by the within-host environment. Using a minimum of modelling assumptions, we find that proportional investment in gametocytogenesis increases sharply with host anaemia and also increases at low parasite densities. Further, stronger dependence of investment on parasite density is associated with greater virulence of the parasite genotype. Our study provides a robust quantitative framework for studying parasites' responses to the host environment and whether these responses are adaptive, which is crucial for predicting the short-term and evolutionary impact of transmission-blocking treatments for parasitic diseases.
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影响因子：
2.9
作者：
CLUTTONBROCK, TH
通讯作者：
CLUTTONBROCK, TH
影响因子：
2.9
作者：
Alizon, Samuel;van Baalen, Minus
通讯作者：
van Baalen, Minus
DOI：
10.1073/pnas.0707221105
发表时间：
2008-01-15
影响因子：
11.1
作者：
Graham, Andrea L.
通讯作者：
Graham, Andrea L.
影响因子：
2.4
作者：
Buckling, A;Ranford-Cartwright, LC;Read, AF
通讯作者：
Read, AF
DOI：
10.1086/596536
发表时间：
2009-03
期刊：
The American naturalist
影响因子：
--
作者：
Fischer B;Taborsky B;Dieckmann U
通讯作者：
Dieckmann U