Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study.
Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study.
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胰岛素增加健康人对高血糖反应的中央主动脉僵硬：一项随机四臂研究。
DOI：
10.1177/14791641211011009
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发表时间：
2021-03
影响因子：
2.4
通讯作者：
Barrett EJ
中科院分区：
文献类型：
--
作者：
Horton WB;Jahn LA;Hartline LM;Aylor KW;Patrie JT;Barrett EJ
动脉硬化增加是血管老化的一个特征，而糖尿病等增加心血管疾病风险的条件会加速血管老化。多项研究表明，糖尿病患者颈-股脉波速度和增强指数存在差异，但其机制尚不清楚。在一项四组随机研究中，我们测试了急性和独立增加血浆葡萄糖、血浆胰岛素或两者同时增加对血液动力学功能和动脉僵硬指标（包括颈-股脉波波速、增强指数、前向和后向波反射振幅和波反射幅度）的影响。动脉-股动脉脉波速度仅在高血糖-高胰岛素血症时增加（+0.36 m/s, p = 0.032），而其他动脉僵硬指标无变化（均p < 0.05）。在高血糖-高胰岛素血症期间，心率（+3.62 bpm, p = 0.009）、平均动脉压（+4.14 mmHg, p = 0.033）、中央舒张压（+4.16 mmHg, p = 0.038）和外周舒张压（+4.09 mmHg, p = 0.044）也显著升高。高血糖-高胰岛素血症会使健康人的cfPWV、心率、平均动脉压和舒张压急剧升高，这可能反映了交感神经张力的增强。反复发作的高血糖伴高胰岛素血症是否会导致动脉僵硬度的慢性增强尚不清楚。
Increasing arterial stiffness is a feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Multiple studies demonstrate divergence of carotid-femoral pulse wave velocity and augmentation index in persons with diabetes mellitus, though mechanisms responsible for this are unclear. We tested the effect of acutely and independently increasing plasma glucose, plasma insulin, or both on hemodynamic function and markers of arterial stiffness (including carotid-femoral pulse wave velocity, augmentation index, forward and backward wave reflection amplitude, and wave reflection magnitude) in a four-arm, randomized study of healthy young adults. Carotid-femoral pulse wave velocity increased only during hyperglycemic-hyperinsulinemia (+0.36 m/s; p = 0.032), while other markers of arterial stiffness did not change (all p > 0.05). Heart rate (+3.62 bpm; p = 0.009), mean arterial pressure (+4.14 mmHg; p = 0.033), central diastolic blood pressure (+4.16 mmHg; p = 0.038), and peripheral diastolic blood pressure (+4.09 mmHg; p = 0.044) also significantly increased during hyperglycemic-hyperinsulinemia. Hyperglycemic-hyperinsulinemia acutely increased cfPWV, heart rate, mean arterial pressure, and diastolic blood pressure in healthy humans, perhaps reflecting enhanced sympathetic tone. Whether repeated bouts of hyperglycemia with hyperinsulinemia contribute to chronically-enhanced arterial stiffness remains unknown.
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影响因子：
24
作者：
Chirinos, Julio A.;Kips, Jan G.;Jacobs, David R., Jr.;Brumback, Lyndia;Duprez, Daniel A.;Kronmal, Richard;Bluemke, David A.;Townsend, Raymond R.;Vermeersch, Sebastian;Segers, Patrick
通讯作者：
Segers, Patrick
影响因子：
20.1
作者：
Donato AJ;Machin DR;Lesniewski LA
通讯作者：
Lesniewski LA
DOI：
10.1152/ajpendo.00300.2020
发表时间：
2020-10-01
影响因子：
5.1
作者：
Horton, William B.;Jahn, Linda A.;Barrett, Eugene J.
通讯作者：
Barrett, Eugene J.
影响因子：
4.8
作者：
Chami, Hassan A.;Vasan, Ramachandran S.;Gottlieb, Daniel J.
通讯作者：
Gottlieb, Daniel J.
影响因子：
37.8
作者：
Beckman, JA;Goldfine, AB;Creager, MA
通讯作者：
Creager, MA