Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre.
Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre.
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DOI：
10.1186/s12969-018-0238-9
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发表时间：
2018-04-02
期刊：
影响因子：
--
通讯作者：
Quartier P
中科院分区：
文献类型：
--
作者：
Goirand M;Breton S;Chevallier F;Duong NP;Uettwiller F;Melki I;Mouy R;Wouters C;Bader-Meunier B;Job-Deslandre C;Quartier P
儿童期起病的脊柱关节病通常始于脊柱炎和外周关节炎。然而，轴性疾病可能会在随后发展。根据修订的(Edmonton 2011)ILAR标准，患者最常被归类为脊柱炎相关性关节炎、牛皮癣关节炎或未分类的幼年特发性关节炎，尤其是在患者或其一级亲属患有牛皮癣的病例中。在成人中，外周性脊柱炎按AS标准进行分类.我们在我们的转诊中心对儿童期脊椎关节病患者进行了一年以上的回顾性研究。我们没有排除有牛皮癣个人或家族病史的患者。我们纳入了2008年1月至2015年12月期间随访的114名患者，中位数为2.5年(IQR = 2.3)。69%的患者符合ILAR修订的脊柱炎相关性关节炎的分类标准，92%的患者符合外周脊柱性关节炎的标准(p <； ，0.001)。在发病时，轴性疾病和骶髂炎很少见。然而，在中位病程分别为2.6年(IC95%[2.2-4.4])和5.3年(IC95%[4.1-7.7])的病例中，分别有63%和47%的病例在随访期出现。多因素分析显示，脊柱性关节炎家族史与最近一次随访时有无活动疾病和腰椎炎有关(OR = 3.61[1.5~8.7]，p <； 分别为0.01和2.98[1.2~7.3]，p = 分别为0.02和0.02)。大多数患者在5年内发生轴心受累。修订后的Edmonton标准在将患者归类为儿童期起病脊柱关节病方面不如ASAS标准敏感.腰椎炎和持续性活动性疾病的主要危险因素是脊柱性关节炎家族史。本文的在线版本(10.1186/s12969-0180238-9)包含向授权用户提供的补充材料。
Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or unclassified juvenile idiopathic arthritis, particularly in cases of psoriasis in the patient or a first-degree relative. In adults, peripheral spondyloarthritis is classified by ASAS criteria. We retrospectively studied patients with childhood-onset spondyloarthropathies followed for more than one year in our referral centre. We did not exclude patients with a personal or familial history of psoriasis. We included 114 patients followed between January 2008 and December 2015 for a median of 2.5 years (IQR = 2.3). Sixty-nine per-cent of patients fulfilled the revised ILAR classification criteria for enthesitis-related arthritis, and 92% the ASAS criteria for peripheral spondyolarthritis (p < 0.001). Axial disease and sacroiliitis were rare at disease onset. However, they appeared during follow-up in 63% and 47% of cases respectively, after a median disease duration of 2.6 (IC 95% [2.2–4.4]) and 5.3 years (IC 95% [4.1–7.7]), respectively. Multivariable analysis showed that familial history of spondyloarthritis was associated with the presence of sacroiliitis and active disease at the latest follow-up (OR = 3.61 [1.5–8.7], p < 0.01 and 2.98 [1.2–7.3], p = 0.02, respectively). Axial involvement developed in most patients within five years. Revised Edmonton criteria were less sensitive than ASAS criteria to classify patients as having childhood-onset spondyloarthropathies. The main risk factor for both sacroiliitis and persistent active disease was a familial history of spondyloarthritis. The online version of this article (10.1186/s12969-018-0238-9) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Pagnini, Ilaria;Savelli, Sara;Simonini, Gabriele
通讯作者：
Simonini, Gabriele
影响因子：
--
作者：
Minden, K;Niewerth, M;Zink, A
通讯作者：
Zink, A
影响因子：
--
作者：
Flato, Berit;Hoffmann-Vold, Anna-Maria;Vinje, Odd
通讯作者：
Vinje, Odd
影响因子：
2.3
作者：
Ramanathan, Anusha;Srinivasalu, Hemalatha;Colbert, Robert A.
通讯作者：
Colbert, Robert A.
影响因子：
4.9
作者：
Horneff G;Fitter S;Foeldvari I;Minden K;Kuemmerle-Deschner J;Tzaribacev N;Thon A;Borte M;Ganser G;Trauzeddel R;Huppertz HI
通讯作者：
Huppertz HI