Variation in Microbial Exposure at the Human-Animal Interface and the Implications for Microbiome-Mediated Health Outcome.
Variation in Microbial Exposure at the Human-Animal Interface and the Implications for Microbiome-Mediated Health Outcome.
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DOI：
10.1128/msystems.00567-21
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发表时间：
2021-08-31
期刊：
影响因子：
6.4
通讯作者：
Reese AT
中科院分区：
文献类型：
--
作者：
Kuthyar S;Reese AT
人类肠道微生物组在人群之间存在差异，这在很大程度上反映了生态差异。一个很少被考虑但可能对微生物组变异有重大贡献的生态变量是人-动物界面的多面性。我们提出的假设是，与动物的不同相互作用有助于在全球范围内塑造人类微生物组。我们利用一个健康框架来探索人类-动物界面微生物暴露的变化如何塑造微生物组，进而有助于不同人群的人类健康差异，重点关注细菌和病原体暴露，殖民抵抗力和免疫系统训练的变化以及其他功能转变的潜力。虽然人类-动物界面是人类健康，特别是传染病差异的基础，但由于它们对人类微生物组的影响仍然严重不足，我们提出了未来研究的重点。我们认为，了解生物学的这一重要方面及其对地球仪各地人类健康的影响至关重要。
The human gut microbiome varies between populations, largely reflecting ecological differences. One ecological variable that is rarely considered but may contribute substantially to microbiome variation is the multifaceted nature of human-animal interfaces. We present the hypothesis that different interactions with animals contribute to shaping the human microbiome globally. We utilize a One Health framework to explore how changes in microbial exposure from human-animal interfaces shape the microbiome and, in turn, contribute to differential human health across populations, focusing on commensal and pathogen exposure, changes in colonization resistance and immune system training, and the potential for other functional shifts. Although human-animal interfaces are known to underlie human health and particularly infectious disease disparities, since their impact on the human microbiome remains woefully understudied, we propose foci for future research. We believe it will be crucial to understand this critical aspect of biology and its impacts on human health around the globe.
DOI：
10.1073/pnas.2020709117
发表时间：
2020-11-24
影响因子：
11.1
作者：
Easterday WR
通讯作者：
Easterday WR