Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex
Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex
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硬骨鱼 HoxD 和 HoxA 基因：与四足动物的比较和 HOXD 复合体的功能进化
DOI：
10.1016/0925-4773(95)00455-6
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发表时间：
1996
影响因子：
2.6
通讯作者：
D. Duboule
中科院分区：
文献类型：
--
作者：
F. Hoeven;P. Sordino;Nadine Fraudeau;J. Izpisúa;D. Duboule
在四足动物中，Hox基因对于轴向结构的正确组织和发育至关重要。涉及Hox基因失活的实验已经揭示了它们在同色异谱系列（如脊柱）内建立形态转变中的特别重要的功能。硬骨鱼显示出一个简单得多的轴向（躯干或apapproxular）形态，这促使我们调查的Hox系统在这些较低的脊椎动物的性质。在这里，我们表明，鱼类有一个家庭的Hox基因，非常相似的数量和一般组织，四足动物。用HoxD和HoxA基因进行的表达研究表明，所有脊椎动物都使用相同的一般方案，涉及基因表达在空间和时间上的共线激活。四足动物和鱼类之间的比较，使我们能够提出一个模型，占这个基因家族的主要功能。在这个模型中，一些祖先的Hox基因参与了消化道极性的决定，并在更复杂的轴结构中进一步招募。
In tetrapods, Hox genes are essential for the proper organization and development of axial structures. Experiments involving Hox gene inactivations have revealed their particularly important functions in the establishment of morphological transitions within metameric series such as the vertebral column. Teleost fish show a much simpler range of axial (trunk or appendicular) morphologies, which prompted us to investigate the nature of the Hox system in these lower vertebrates. Here, we show that fish have a family of Hox genes, very similar in both number and general organization, to that of tetrapods. Expression studies, carried out with HoxD and HoxA genes, showed that all vertebrates use the same general scheme, involving the colinear activation of gene expression in both space and time. Comparisons between tetrapods and fish allowed us to propose a model which accounts for the primary function of this gene family. In this model, a few ancestral Hox genes were involved in the determination of polarity in the digestive tract and were further recruited in more elaborate axial structures.
影响因子：
4.6
作者：
A. Burke;Craig E. Nelson;B. Morgan
通讯作者：
A. Burke;Craig E. Nelson;B. Morgan