Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
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DOI：
10.1038/onc.2008.343
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发表时间：
2008-11-24
期刊：
影响因子：
8
通讯作者：
Yap, A. S.
中科院分区：
文献类型：
--
作者：
Jeanes, A.;Gottardi, C. J.;Yap, A. S.
细胞间粘附受体E-cadherin是肿瘤进展的重要决定因素，在许多情况下作为侵袭和转移的抑制因子。然而，E-cadherin功能的丧失如何促进肿瘤进展还知之甚少。本文就E-cadherin在经典Wnt通路中调控β-catenin信号传导的能力、E-cadherin通过生长因子受体抑制促有丝分裂信号传导的潜力以及E-cadherin与上皮细胞极性分子决定因素之间的可能联系等三个方面进行综述。这些潜在机制中的每一个都提供了对可能负责E-钙粘蛋白的肿瘤抑制作用的复杂性的见解。
It has long been recognized that the cell–cell adhesion receptor, E-cadherin, is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis in many contexts. Yet how the loss of E-cadherin function promotes tumor progression is poorly understood. In this review, we focus on three potential underlying mechanisms: the capacity of E-cadherin to regulate β-catenin signaling in the canonical Wnt path-way; its potential to inhibit mitogenic signaling through growth factor receptors and the possible links between cadherins and the molecular determinants of epithelial polarity. Each of these potential mechanisms provides insights into the complexity that is likely responsible for the tumor-suppressive action of E-cadherin.
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