Organizing for ontological change: The kernel of an AIDS research infrastructure
Organizing for ontological change: The kernel of an AIDS research infrastructure
复制标题
组织本体论变革：艾滋病研究基础设施的核心
作者：
David Ribes;J. B. Polk
是否有可能为新兴和不断变化的研究对象做好准备和计划？多中心艾滋病队列研究的成员对艾滋病的研究已有 30 多年的历史，在此期间，这种疾病已多次发生变化。多年来，经历了许多变化，成员们继续研究艾滋病毒疾病，同时重建一个适应性强的研究组织。维持这种技术科学灵活性的关键是我们所说的研究基础设施的核心：不断努力维持可用于新物体研究的资源和服务的可用性。就多中心艾滋病队列研究而言，这些资源如下：样本和数据、校准仪器、异质专家以及参与的男同性恋和双性恋队列。我们跟踪三个本体论转变，检查成员如何准备和应对变化：新型逆转录病毒药物（HIV）的发现、测试该药物的能力以及通过药物干预将疾病从致命性转变为慢性疾病。我们分别将这项工作称为“技术”和适应这些变化的技术“重新调整用途”、“精心设计”和“扩展内核”。
Is it possible to prepare and plan for emergent and changing objects of research? Members of the Multicenter AIDS Cohort Study have been investigating AIDS for over 30 years, and in that time, the disease has been repeatedly transformed. Over the years and across many changes, members have continued to study HIV disease while in the process regenerating an adaptable research organization. The key to sustaining this technoscientific flexibility has been what we call the kernel of a research infrastructure: ongoing efforts to maintain the availability of resources and services that may be brought to bear in the investigation of new objects. In the case of the Multicenter AIDS Cohort Study, these resources are as follows: specimens and data, calibrated instruments, heterogeneous experts, and participating cohorts of gay and bisexual men. We track three ontological transformations, examining how members prepared for and responded to changes: the discovery of a novel retroviral agent (HIV), the ability to test for that agent, and the transition of the disease from fatal to chronic through pharmaceutical intervention. Respectively, we call the work, ‘technologies’, and techniques of adapting to these changes, ‘repurposing’, ‘elaborating’, and ‘extending the kernel’.
DOI：
10.1007/s10606-012-9184-0
发表时间：
2013-08-01
影响因子：
2.4
作者：
Jirotka, Marina;Lee, Charlotte P.;Olson, Gary M.
通讯作者：
Olson, Gary M.
从文物到基础设施
DOI：
10.1007/s10606-012-9167-1
发表时间：
2012
期刊：
Computer Supported Cooperative Work (CSCW)
影响因子：
--
作者：
Monteiro E
通讯作者：
Monteiro E
条形码自然：生物多样性丧失时代分类学文化的转变
DOI：
--
发表时间：
2014
期刊：
--
影响因子：
--
作者：
Waterton
通讯作者：
Waterton