Combined Effects of Repetitive Mild Traumatic Brain Injury and Alcohol Drinking on the Neuroinflammatory Cytokine Response and Cognitive Behavioral Outcomes.
Combined Effects of Repetitive Mild Traumatic Brain Injury and Alcohol Drinking on the Neuroinflammatory Cytokine Response and Cognitive Behavioral Outcomes.
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DOI：
10.3390/brainsci10110876
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发表时间：
2020-11-19
期刊：
影响因子：
3.3
通讯作者：
Kindy MS
中科院分区：
文献类型：
--
作者：
Hoffman J;Yu J;Kirstein C;Kindy MS
饮酒与创伤性脑损伤（TBI）之间的关系通常集中在饮酒增加了发生TBI的可能性，而不是TBI后饮酒的结果。然而，没有酒精使用障碍史的患者也可能在单次或多次TBI后出现饮酒问题。酒精和轻度TBI共享弥漫性有害的神经系统影响和认知障碍;因此，这些研究的目的是确定当TBI后纵向饮酒时，是否会发生对大脑和行为结果的相互作用。为了检查轻度重复TBI（rmTBI）对自愿饮酒的影响，在2周的时间内使小鼠经受4次轻度TBI或假手术，然后使用两瓶选择提供酒精（20%v/v）2周，在黑暗中饮用方案。在饮酒期后，评估小鼠的神经炎性细胞因子反应或测试认知和行为缺陷。结果表明，与假手术相比，rmTBI后饮酒或偏好无差异;然而，观察到rmTBI和饮酒后饮酒引起的神经炎性细胞因子反应增加和一些轻度认知行为缺陷。这些数据表明，对饮酒和rmTBI +饮酒的细胞因子反应不一定是聚集的，但组合确实导致认知行为结果的恶化。
The relationship between alcohol consumption and traumatic brain injury (TBI) often focuses on alcohol consumption increasing the likelihood of incurring a TBI, rather than alcohol use outcomes after TBI. However, patients without a history of an alcohol use disorder can also show increased problem drinking after single or multiple TBIs. Alcohol and mild TBI share diffuse deleterious neurological impacts and cognitive impairments; therefore, the purpose of these studies was to determine if an interaction on brain and behavior outcomes occurs when alcohol is consumed longitudinally after TBI. To examine the impact of mild repetitive TBI (rmTBI) on voluntary alcohol consumption, mice were subjected to four mild TBI or sham procedures over a 2 week period, then offered alcohol (20% v/v) for 2 weeks using the two-bottle choice, drinking in the dark protocol. Following the drinking period, mice were evaluated for neuroinflammatory cytokine response or tested for cognitive and behavioral deficits. Results indicate no difference in alcohol consumption or preference following rmTBI as compared to sham; however, increases in the neuroinflammatory cytokine response due to alcohol consumption and some mild cognitive behavioral deficits after rmTBI and alcohol consumption were observed. These data suggest that the cytokine response to alcohol drinking and rmTBI + alcohol drinking is not necessarily aggregate, but the combination does result in an exacerbation of cognitive behavioral outcomes.
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影响因子：
3.3
作者：
Delouche, Aurelie;Attye, Arnaud;Krainik, Alexandre
通讯作者：
Krainik, Alexandre
影响因子：
10.6
作者：
Crews, Fulton T.;Qin, Liya;Sheedy, Donna;Vetreno, Ryan P.;Zou, Jian
通讯作者：
Zou, Jian
影响因子：
1.9
作者：
Brasiliano Ferreira, Luiz Carlos;Regner, Andrea;Simon, Daniel
通讯作者：
Simon, Daniel
影响因子：
--
作者：
Fann, JR;Burington, B;Thompson, RS
通讯作者：
Thompson, RS
DOI：
10.1111/j.1530-0277.1996.tb01641.x
发表时间：
1996-04-01
影响因子：
3.2
作者：
Collins, MA;Corso, TD;Neafsey, EJ
通讯作者：
Neafsey, EJ