Mutations in the flhD gene of Escherichia coli K-12 do not cause the reported effect on cell division.

Mutations in the flhD gene of Escherichia coli K-12 do not cause the reported effect on cell division.
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大肠杆菌 K-12 的 flhD 基因突变不会对细胞分裂产生所报告的影响。

DOI:
10.1111/j.1574-6968.2010.02021.x
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发表时间:
2010
影响因子:
2.1
通讯作者:
Mao,Weimin
Mao,Weimin
中科院分区:
生物学4区
文献类型:
--
作者:
Siegele,DeborahA;Bain,Sherrie;Mao,Weimin

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The hetero-oligomeric FlhD/FlhC complex is a global regulator of transcription inEscherichia coli. FlhD alone, independent of FlhC, has also been reported to control whenE. colicells stop dividing and enter the stationary phase. This work is frequently cited as evidence that FlhD regulates cell division; however, our data indicate that this is not the case. The results presented here show that the previously observed phenotype is not due to theflhDlocus, but is instead due to differences in thethyAalleles present in theflhD+andflhD−strains used in the original studies. We find that when the strains being compared have the samethyAallele (wild type or mutant),flhDmutations have no effect on growth.
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