18F-FDG PET/CT for image-guided and intensity-modulated radiotherapy.

18F-FDG PET/CT for image-guided and intensity-modulated radiotherapy.
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DOI:
10.2967/jnumed.108.055780
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发表时间:
2009-10
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
通讯作者:
Wahl RL
Wahl RL
中科院分区:
其他
文献类型:
--
作者:
Ford EC;Herman J;Yorke E;Wahl RL

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Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and neck cancer, and pancreatic adenocarcinoma. This review focuses on the use of 18F-FDG PET/CT to aid in planning radiotherapy and the associated benefits and challenges. We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning.
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