Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.

Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries.
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DOI:
10.1038/ijos.2012.54
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发表时间:
2012-09
影响因子:
14.9
通讯作者:
Burne, Robert A.
Burne, Robert A.
中科院分区:
医学1区
文献类型:
--
作者:
Liu, Ya-Ling;Nascimento, Marcelle;Burne, Robert A.

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口腔细菌产生的碱被认为对口腔微生物生态有重大影响,并对龋齿的发生和发展有抑制作用。大量的证据开始积累,表明调节牙齿生物膜的碱性潜能可能是一种很有前途的龋齿控制策略。本文简要回顾了口腔细菌中重要的产碱途径的分子遗传学和生理学方面的最新进展,以及产碱在健康和疾病中牙齿生物膜生态中的作用。
Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.
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