Apoptosis in cancer: from pathogenesis to treatment.
Apoptosis in cancer: from pathogenesis to treatment.
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DOI：
10.1186/1756-9966-30-87
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发表时间：
2011-09-26
期刊：
影响因子：
--
通讯作者：
Wong RS
中科院分区：
文献类型：
--
作者：
Wong RS
细胞凋亡是发生在生理和病理条件下的有序和协调的细胞过程。它也是细胞生物学家研究最多的课题之一。细胞凋亡在许多疾病的发病机制中起着关键作用，因此了解其潜在机制非常重要。在一些情况下，问题是由于太多的凋亡，例如在退行性疾病的情况下，而在其他情况下，太少的凋亡是罪魁祸首。癌症是细胞凋亡发生太少的情况之一，导致恶性细胞不会死亡。细胞凋亡的机制是复杂的，涉及许多途径。缺陷可发生在这些通路的任何沿着点，导致受影响细胞的恶性转化、肿瘤转移和对抗癌药物的抗性。尽管是问题的原因，但细胞凋亡在癌症的治疗中起着重要作用，因为它是许多治疗策略的流行靶点。大量的文献表明，靶向肿瘤细胞凋亡是可行的。然而，许多令人不安的问题出现与使用新的药物或治疗策略，旨在提高细胞凋亡和关键的测试必须通过之前，他们可以安全地用于人类受试者。
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.
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影响因子：
3.8
作者：
Avery-Kiejda KA;Bowden NA;Croft AJ;Scurr LL;Kairupan CF;Ashton KA;Talseth-Palmer BA;Rizos H;Zhang XD;Scott RJ;Hersey P
通讯作者：
Hersey P
DOI：
10.1006/bbrc.1999.1585
发表时间：
1999-11-02
影响因子：
3.1
作者：
Chen, ZH;Naito, M;Tsuruo, T
通讯作者：
Tsuruo, T
影响因子：
12.8
作者：
Du, Zhen-Xian;Zhang, Hai-Yan;Liu, Guo-Liang
通讯作者：
Liu, Guo-Liang
影响因子：
11.4
作者：
Friesen, C;Fulda, S;Debatin, KM
通讯作者：
Debatin, KM
影响因子：
3.4
作者：
Fong, PY;Xue, WC;Cheung, ANY
通讯作者：
Cheung, ANY