Synaptic functions of endocannabinoid signaling in health and disease.
Synaptic functions of endocannabinoid signaling in health and disease.
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DOI：
10.1016/j.neuropharm.2017.06.017
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发表时间：
2017-09-15
影响因子：
4.7
通讯作者：
Tonini R
中科院分区：
文献类型：
--
作者：
Araque A;Castillo PE;Manzoni OJ;Tonini R
内源性大麻素（eCB）是一个家族的脂质分子，作为突触传递和可塑性的关键调节剂。它们在生理和/或病理刺激后“按需”合成。一旦从突触后神经元释放，eCB通常充当逆行信使以激活突触前1型大麻素受体（CB 1）并诱导神经递质释放的短期或长期抑制。除了这种典型的作用机制，最近的研究结果揭示了一些不太传统的机制，eCB调节神经活动和突触功能，这表明eCB介导的可塑性在机制上比预期的更多样化。这些机制包括非逆行信号传导、通过星形胶质细胞的信号传导、参与长时程增强以及线粒体CB 1的参与。本文以海马、纹状体和新皮层等典型脑区为重点，综述了典型和新颖的信号传导机制，并讨论了其在正常脑功能和脑疾病中的功能意义。总之，eCB信号传导可以通过激活过多的机制导致不同形式的突触可塑性，这为eCB信号传导的功能结果提供了进一步的复杂性。
Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of synaptic transmission and plasticity. They are synthetized “on demand” following physiological and/or pathological stimuli. Once released from postsynaptic neurons, eCBs typically act as retrograde messengers to activate presynaptic type 1 cannabinoid receptors (CB1) and induce short- or long-term depression of neurotransmitter release. Besides this canonical mechanism of action, recent findings have revealed a number of less conventional mechanisms by which eCBs regulate neural activity and synaptic function, suggesting that eCB-mediated plasticity is mechanistically more diverse than anticipated. These mechanisms include non-retrograde signaling, signaling via astrocytes, participation in long-term potentiation, and the involvement of mitochondrial CB1. Focusing on paradigmatic brain areas, such as hippocampus, striatum, and neocortex, we review typical and novel signaling mechanisms, and discuss the functional implications in normal brain function and brain diseases. In summary, eCB signaling may lead to different forms of synaptic plasticity through activation of a plethora of mechanisms, which provide further complexity to the functional consequences of eCB signaling.
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DOI：
10.1016/j.pnpbp.2013.12.002
发表时间：
2014-04-03
影响因子：
5.6
作者：
Bystrowska, Beata;Smaga, Irena;Filip, Malgorzata
通讯作者：
Filip, Malgorzata
影响因子：
25
作者：
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通讯作者：
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影响因子：
25
作者：
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通讯作者：
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影响因子：
16.2
作者：
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通讯作者：
Pereda, Alberto E.
DOI：
10.1073/pnas.1009874107
发表时间：
2010-08-17
影响因子：
11.1
作者：
Bateup, Helen S.;Santini, Emanuela;Greengard, Paul
通讯作者：
Greengard, Paul