Comparison of salivary steroid profiles in naturally occurring conception and non-conception cycles.
Comparison of salivary steroid profiles in naturally occurring conception and non-conception cycles.
复制标题
自然受孕周期和非受孕周期中唾液类固醇分布的比较。
作者：
S. Lipson;P. T. Ellison
雌二醇和孕酮的配置文件从自然发生的概念和暴露的非概念周期进行了比较，以评估卵巢类固醇激素的浓度自然变化对女性生育力的影响。在一项前瞻性的纵向研究中，24名妇女每天收集两次唾液样本，并记录长达1年的性交，或直到临床确认怀孕。雌二醇和孕酮浓度测定唾液放射免疫法。平均卵泡中期雌二醇浓度在妊娠期显著高于非妊娠期（12.6 +/- 1.7 vs 8.5 +/- 0.6 pmol/l，P < 0.01）。一项单独的分析，仅包括那些既有妊娠周期又有非妊娠周期的妇女的周期，表明卵泡中期雌二醇浓度的差异更为明显，而不仅仅是妊娠周期和非妊娠周期的差异（14.5 +/- 2.3与6.5 +/- 0.7 pmol/l，P < 0.001），而且在个体女性的受孕浓度和平均非受孕浓度之间也存在差异。在这些妇女中，相对卵泡中期雌二醇浓度与成功受孕的概率高度相关。此外，相对体重与卵泡中期雌二醇浓度呈显著正相关。这些结果表明，卵泡发育的变化，反映在卵泡雌二醇浓度的变化，是一个重要的生育力指标。
Oestradiol and progesterone profiles from naturally occurring conception and exposed non-conception cycles were compared to assess the impact of natural variation in concentrations of ovarian steroid hormones on female fecundity. In a prospective, longitudinal study, 24 women collected saliva samples twice daily and recorded intercourse for up to 1 year or until a pregnancy was clinically confirmed. Oestradiol and progesterone concentrations were measured by a salivary radioimmunoassay. Average mid-follicular oestradiol concentrations were significantly higher in conception than in non-conception cycles (12.6 +/- 1.7 versus 8.5 +/- 0.6 pmol/l, P < 0.01). A separate analysis, including only cycles from those women who contributed both conception and non-conception cycles, demonstrated an even more pronounced difference in mid-follicular oestradiol concentrations, not just for conception and non-conception cycles as groups (14.5 +/- 2.3 versus 6.5 +/- 0.7 pmol/l, P < 0.001), but also between the conception and average non-conception concentrations of individual women. Among these women, relative mid-follicular oestradiol concentration was highly correlated with the probability of successful conception. In addition, relative body weight was significantly positively correlated with mid-follicular oestradiol concentration. These findings indicate that variation in follicular development, reflected in variation in follicular oestradiol concentrations, is an important indicator of fecundity.
在恒河猴中，卵巢刺激过程中类固醇的减少会损害卵母细胞的受精，但不会损害卵泡发生。
影响因子：
6.7
作者：
Zelinski-Wooten,MB;Hess,DL;Wolf,DP;Stouffer,RL
通讯作者：
Stouffer,RL
影响因子：
5.8
作者：
HOFF, JD;QUIGLEY, ME;YEN, SSC
通讯作者：
YEN, SSC
哺乳动物排卵机制的研究。
影响因子：
6.7
作者：
Yoshimura,Y;Wallach,EE
通讯作者：
Wallach,EE