Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.
Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.
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DOI：
10.1038/nrneurol.2018.20
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Sommer C
中科院分区：
文献类型：
--
作者：
Birklein F;Ajit SK;Goebel A;Perez RSGM;Sommer C
复杂区域疼痛综合征（CRPS）是一种通常影响单肢的疼痛状况，通常在受伤后发生。潜在的病理生理学似乎很复杂，可能因患者而异。临床诊断是基于国际商定的标准，考虑报告的症状，体征的存在和排除其他原因。研究CRPS生物标志物以支持患者分层并提高诊断确定性是一个重要的科学焦点，该领域的最新进展为可测量的疾病预测，诊断和预后参数的最新局部审查提供了机会。CRPS的临床和生化属性，可能有助于诊断和确定适当的治疗划定。预测CRPS发展并支持诊断的发现包括创伤相关因素，神经认知特性，心理标志物以及表明免疫系统激活的局部和全身变化。分析非编码microRNA的特征可以预测治疗反应，这是一个新的研究方向。过去5年CRPS研究的结果表明，可能永远不会发现CRPS的单一标志物;然而，一系列生物标志物可能有助于临床诊断并指导预后和治疗。
Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single limb, often following an injury. The underlying pathophysiology seems to be complex and probably varies between patients. Clinical diagnosis is based on internationally agreed-upon criteria, which consider the reported symptoms, presence of signs and exclusion of alternative causes. Research into CRPS biomarkers to support patient stratification and improve diagnostic certainty is an important scientific focus, and recent progress in this area provides an opportunity for an up-to-date topical review of measurable disease-predictive, diagnostic and prognostic parameters. Clinical and biochemical attributes of CRPS that may aid diagnosis and determination of appropriate treatment are delineated. Findings that predict the development of CRPS and support the diagnosis include trauma-related factors, neurocognitive peculiarities, psychological markers, and local and systemic changes that indicate activation of the immune system. Analysis of signatures of non-coding microRNAs that could predict the treatment response represents a new line of research. Results from the past 5 years of CRPS research indicate that a single marker for CRPS will probably never be found; however, a range of biomarkers might assist in clinical diagnosis and guide prognosis and treatment.
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作者：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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