Functional reorganization of the default mode network across chronic pain conditions.
Functional reorganization of the default mode network across chronic pain conditions.
复制标题
DOI：
10.1371/journal.pone.0106133
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Baliki MN;Mansour AR;Baria AT;Apkarian AV
慢性疼痛与神经元可塑性有关。本研究采用静息状态功能磁共振成像技术研究慢性背痛（CBP）、复杂区域疼痛综合征（CRPS）和膝关节骨关节炎（OA）患者的功能变化。我们在各组中分离出五个有意义的静息状态网络，其中只有默认模式网络（DMN）表现出与健康对照的偏差。所有患者组均显示内侧前额叶皮层（MPFC）与DMN后部成分的连通性降低，与岛叶皮层的连通性增加，与疼痛强度成正比。多个DMN区域，特别是MPFC，表现出增加的高频振荡，并伴有与处理注意力相关的顶叶区域相锁的减少。在OA和CBP患者中，阶段和频率变化与疼痛持续时间相关。因此，慢性疼痛似乎重组了DMN的动态，因此反映了不同类型的慢性疼痛的不适应生理。
Chronic pain is associated with neuronal plasticity. Here we use resting-state functional magnetic resonance imaging to investigate functional changes in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA). We isolated five meaningful resting-state networks across the groups, of which only the default mode network (DMN) exhibited deviations from healthy controls. All patient groups showed decreased connectivity of medial prefrontal cortex (MPFC) to the posterior constituents of the DMN, and increased connectivity to the insular cortex in proportion to the intensity of pain. Multiple DMN regions, especially the MPFC, exhibited increased high frequency oscillations, conjoined with decreased phase locking with parietal regions involved in processing attention. Both phase and frequency changes correlated to pain duration in OA and CBP patients. Thus chronic pain seems to reorganize the dynamics of the DMN and as such reflect the maladaptive physiology of different types of chronic pain.
登录
查看更多内容
影响因子：
2.5
作者：
Farmer MA;Baliki MN;Apkarian AV
通讯作者：
Apkarian AV
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
5.7
作者：
Beckmann, CF;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Baliki MN;Schnitzer TJ;Bauer WR;Apkarian AV
通讯作者：
Apkarian AV