Long Noncoding RNAs in Plant-Pathogen Interactions.
Long Noncoding RNAs in Plant-Pathogen Interactions.
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DOI：
10.1094/phyto-02-23-0051-ia
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发表时间：
2023-08
期刊：
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
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作者：
长链非编码rna （lncrna）通常被定义为缺乏蛋白质编码能力且长度超过200个核苷酸的转录本。自本世纪新一代测序技术出现以来，已经从几乎所有生物体中鉴定出数千种lncrna。值得注意的是，各种病原体在感染过程中也在宿主细胞中表达自己的lncrna。在植物中，许多lncrna在响应环境刺激（包括病原体攻击）时表现出动态表达模式。与鉴定这类lncrna的成熟方法相比，目前对lncrna功能机制的了解尚处于起步阶段。一些lncRNAs作为生成小rna的前体或作为分离功能性小rna的靶模拟物，这在文献中已经得到了广泛的综述。这篇综述的重点是支持某些lncrna作为植物免疫的负或正调节因子的新证据。一个共同的主题是，这些调控依赖于lncrna和关键调控蛋白之间的特定相互作用。作为单链环状非编码RNA的类病毒提供了一个研究RNA局部基序如何在lncRNAs和调控蛋白之间呈现相互作用特异性的方法。
Long noncoding RNAs (lncRNAs) are commonly defined as transcripts that lack protein-coding capacity and are longer than 200 nucleotides. Since the emergence of next-generation sequencing technologies in this century, thousands of lncRNAs have been identified from nearly all living organisms. Notably, various pathogens also express their own lncRNAs in host cells during infection. In plants, many lncRNAs exhibit dynamic expression patterns in response to environmental stimuli, including pathogen attacks. In contrast to well-established methods in identifying such lncRNAs, the current understanding of lncRNAs’ functional mechanisms is in its infancy. Some lncRNAs serve as precursors for generating small RNAs or serve as target mimics to sequester functional small RNAs, which have been extensively reviewed in the literature. This review focuses on the emerging evidence supporting that certain lncRNAs function as negative or positive regulators of plant immunity. A common theme is that those regulations rely on specific interactions between lncRNAs and key regulatory proteins. Viroids as single-stranded circular noncoding RNAs provide a handle to investigate how RNA local motifs render interaction specificity between lncRNAs and regulatory proteins.
全面的转录组分析表明，番茄植物对基于烟草病毒的基因沉默载体的反应。
影响因子：
4.6
作者：
Zheng Y;Ding B;Fei Z;Wang Y
通讯作者：
Wang Y
DOI：
10.3390/v13112129
发表时间：
2021-10-22
期刊：
Viruses
影响因子：
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作者：
Kang SH;Aknadibossian V;Kharel L;Mudiyanselage SDD;Wang Y;Folimonova SY
通讯作者：
Folimonova SY