Challenges and recent progress in drug discovery for tropical diseases.

Challenges and recent progress in drug discovery for tropical diseases.
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DOI:
10.1038/s41586-018-0327-4
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发表时间:
2018-07
期刊:
影响因子:
64.8
通讯作者:
Gilbert IH
Gilbert IH
中科院分区:
综合性期刊1区
文献类型:
--
作者:
De Rycker M;Baragaña B;Duce SL;Gilbert IH

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热带传染病在死亡率和发病率方面影响巨大,并给受影响的国家带来沉重的经济负担。这些疾病主要影响世界上最贫穷的人。目前可用的药物不足以治疗这些疾病中的大多数,迫切需要新的治疗方法。这篇综述讨论了开发治疗这些疾病的新药所涉及的一些挑战,并强调了最近的进展。虽然已经取得了显著的成功,但仍有很长的路要走。
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.
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