Chagas disease research and development: Is there light at the end of the tunnel?
Chagas disease research and development: Is there light at the end of the tunnel?
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DOI：
10.1016/j.csbj.2016.12.002
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发表时间：
2017
影响因子：
6
通讯作者：
Chatelain E
中科院分区：
文献类型：
--
作者：
Chatelain E
恰加斯病，或美国锥虫病，是由寄生虫克氏锥虫感染的结果。它是拉丁美洲的地方病，由于人类迁徙而在全球蔓延。虽然它在一个多世纪前被首次发现，但目前只有两种古老的药物可用于治疗，许多与疾病进展、其病理机制有关的问题，更不用说治疗效果的评估，仍然存在争议和有待回答。事实上，目前现有的证据和数据状况不允许对查加斯患者的治疗需求和结果作出任何绝对声明。尽管在最近的新的临床试验之后，恰加斯病的研究和开发有了一些新的动力，但有一个科学要求来审查和质疑目前的证据状况，并确定该领域的基础和临床研究优先事项和下一步行动。这将确保开发出治疗恰加斯病的最佳药物，但这将需要整个恰加斯病研究界的集中和合作努力。
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment of treatment efficacy, are subject to debate and remain to be answered. Indeed, the current status of evidence and data available does not allow any absolute statement related to treatment needs and outcome for Chagas patients to be made. Although there has been some new impetus in Research and Development for Chagas disease following recent new clinical trials, there is a scientific requirement to review and challenge the current status of evidence and define basic and clinical research priorities and next steps in the field. This should ensure that the best drugs for Chagas disease are developed, but will require a focused and collaborative effort of the entire Chagas disease research community.
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