New Insights into the Role of the Complement System in Human Viral Diseases.
New Insights into the Role of the Complement System in Human Viral Diseases.
复制标题
DOI：
10.3390/biom12020226
复制
发表时间：
2022-01-28
期刊：
影响因子：
5.5
通讯作者：
Hukowska-Szematowicz B
中科院分区：
文献类型：
--
作者：
Ostrycharz E;Hukowska-Szematowicz B
The complement system (CS) is part of the human immune system, consisting of more than 30 proteins that play a vital role in the protection against various pathogens and diseases, including viral diseases. Activated via three pathways, the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP), the complement system leads to the formation of a membrane attack complex (MAC) that disrupts the membrane of target cells, leading to cell lysis and death. Due to the increasing number of reports on its role in viral diseases, which may have implications for research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this review aims to highlight significant progress in understanding and defining the role of the complement system in four groups of diseases of viral etiology: (1) respiratory diseases; (2) acute liver failure (ALF); (3) disseminated intravascular coagulation (DIC); and (4) vector-borne diseases (VBDs). Some of these diseases already present a serious global health problem, while others are a matter of concern and require the collaboration of relevant national services and scientists with the World Health Organization (WHO) to avoid their spread.
登录
查看更多内容
影响因子：
4.6
作者：
Chuang YC;Chen HR;Yeh TM
通讯作者：
Yeh TM
影响因子：
4.4
作者：
Bosmann, Markus;Haggadone, Mikel D.;Ward, Peter A.
通讯作者：
Ward, Peter A.
DOI：
10.1038/nri3166
发表时间：
2012-03-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Carvelli, Julien;Demaria, Olivier;Vivier, Eric
通讯作者：
Vivier, Eric
影响因子：
3.1
作者：
Cepkova, Magda;Matthay, Michael A
通讯作者：
Matthay, Michael A