Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection.
Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection.
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DOI：
10.1155/2015/547094
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发表时间：
2015
影响因子：
4.6
通讯作者：
Yeh TM
中科院分区：
文献类型：
--
作者：
Chuang YC;Chen HR;Yeh TM
登革病毒（DENV）感染是病毒性出血热的最常见原因，可导致危及生命的登革出血热/登革休克综合征（DHF/DSS）。出血和血浆渗漏是DHF/DSS的两个主要特征。由于引起这些致病变化的机制尚不清楚，目前尚无针对DHF/DSS的有效治疗方法。在这篇综述中，我们主要关注多效性细胞因子巨噬细胞迁移抑制因子（MIF）在DENV感染发病机制中的可能致病作用。MIF是宿主免疫反应和炎症的重要介质，登革热患者血清中MIF水平与疾病严重程度之间存在相关性。此外，MIF敲除小鼠表现出较轻的临床疾病和致死率。然而，MIF在DHF/DSS发病机制中的作用并不局限于免疫细胞募集。最近的证据表明，DENV感染诱导了MIF的产生，并可能导致DENV感染期间血管的高通透性和病毒复制。在mif刺激的单核细胞和内皮细胞上，粘附和凝血分子的表达也增加，这可能有助于DHF/DSS期间的炎症和抗凝状态。因此，阻断MIF的产生或其功能可能为DHF/DSS的治疗和预防提供一种解决方案。
Dengue virus (DENV) infection is the most common cause of viral hemorrhagic fever, which can lead to life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Hemorrhage and plasma leakage are two major hallmarks of DHF/DSS. Because the mechanisms causing these pathogenic changes are unclear, there is no effective therapy against DHF/DSS. In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection. MIF is a critical mediator of the host immune response and inflammation, and there is a correlation between the serum levels of MIF and disease severity in dengue patients. Furthermore, MIF knock-out mice exhibit less severe clinical disease and lethality. However, the role of MIF in the pathogenesis of DHF/DSS is not limited to immune cell recruitment. Recent evidence indicates that DENV infection induced MIF production and may contribute to vascular hyperpermeability and viral replication during DENV infection. The expression of both adhesion and coagulation molecules on MIF-stimulated monocytes and endothelial cells is also increased, which may contribute to inflammatory and anticoagulatory states during DHF/DSS. Therefore, blocking MIF production or its function may provide a solution for the treatment and prevention of DHF/DSS.
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影响因子：
6.7
作者：
Asare, Yaw;Schmitt, Martin;Bernhagen, Juergen
通讯作者：
Bernhagen, Juergen
影响因子：
82.9
作者：
Calandra, T;Echtenacher, B;Glauser, MP
通讯作者：
Glauser, MP
DOI：
10.1073/pnas.56.1.72
发表时间：
1966-01-01
影响因子：
11.1
作者：
DAVID, JR
通讯作者：
DAVID, JR
影响因子：
3.8
作者：
Chareonsirisuthigul, Takol;Kalayanarooj, Siripen;Ubol, Sukathida
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Ubol, Sukathida
巨噬细胞是巨噬细胞迁移抑制因子的重要且以前未被认可的来源。
影响因子：
15.3
作者：
Calandra, Thierry;Bernhagen, Juergen;Mitchell, Robert A.;Bucala, Richard
通讯作者：
Bucala, Richard