Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis.
Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis.
复制标题
DOI：
10.7326/0003-4819-156-9-201205010-00006
复制
发表时间：
2012-05-01
影响因子：
39.2
通讯作者：
Miglioretti DL
中科院分区：
文献类型：
--
作者：
Nelson HD;Zakher B;Cantor A;Fu R;Griffin J;O'Meara ES;Buist DS;Kerlikowske K;van Ravesteyn NT;Trentham-Dietz A;Mandelblatt JS;Miglioretti DL
确定40多岁女性乳腺癌的风险因素可以为筛查决策提供信息。确定哪些因素会增加40-49岁女性患乳腺癌的风险，以及每个因素的风险程度。MEDLINE（1996年1月至2011年11月）、科克伦对照试验中心注册中心和科克伦系统评价数据库（2011年第四季度）、Scopus和已发表研究的参考文献列表;以及来自乳腺癌监测联盟（BCSC）的数据。40-49岁女性乳腺癌危险因素的英语研究和系统评价。对每个风险因素应用了额外的纳入标准。对参与者、研究设计、分析、随访和结局的数据进行了抽象。使用既定标准对研究质量进行评级，仅纳入评级为良好或一般的研究。当有足够的研究时，使用荟萃分析总结结果，或者当荟萃分析不可能时，根据研究质量、规模和适用性的最佳证据总结结果。BCSC数据采用部分条件考克斯回归的比例风险模型进行分析。用于比较的参考组设定为美国人群平均值。65项研究提供了估计数据。乳腺X线摄影显示乳腺密度极高或一级亲属患有乳腺癌与乳腺癌增加≥2倍相关。既往乳腺活检、乳腺癌的二级亲属或乳腺密度不均与风险增加1.5-2.0相关;当前口服避孕药使用、未生育和首次生育年龄≥30岁与风险增加1.0-1.5相关。研究因测量、参考组和混杂因素调整而不同;未考虑多种风险因素的影响。在40-49岁的女性中，极致密乳房和一级亲属患乳腺癌均与乳腺癌风险增加≥2倍相关。识别这些危险因素可能有助于个性化的乳腺X线筛查。国家癌症研究所促进研究合作活动补充（U 01 CA 086076 - 10 S1）。数据收集得到美国国家癌症研究所资助的乳腺癌监测联盟（BCSC）合作协议（U 01 CA 63740、U 01 CA 86076、U 01 CA 86082、U 01 CA 63736、U 01 CA 70013、U 01 CA 69976、U 01 CA 63731、U 01 CA 70040）的支持。
Identifying risk factors for breast cancer specific to women in their forties could inform screening decisions. To determine what factors increase risk for breast cancer in women age 40–49 years and the magnitudes of risk for each factor. MEDLINE (January 1996 to November 2011), Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (fourth Quarter 2011), Scopus, and reference lists for published studies; and data from the Breast Cancer Surveillance Consortium (BCSC). English-language studies and systematic reviews of risk factors for breast cancer in women age 40–49 years. Additional inclusion criteria were applied for each risk factor. Data on participants, study design, analysis, follow-up, and outcomes were abstracted. Study quality was rated using established criteria and only studies rated good or fair were included. Results were summarized using meta-analysis when sufficient studies were available, or from the best evidence based on study quality, size, and applicability when meta-analysis was not possible. BCSC data were analyzed with proportional hazards models using partly conditional Cox regression. Reference groups for comparisons were set at U.S. population means. 65 studies provided data for estimates. Extremely dense breasts on mammography or first-degree relatives with breast cancer were associated with ≥2-fold increase in breast cancer. Prior breast biopsy, second degree relatives with breast cancer, or heterogeneously dense breasts were associated with 1.5–2.0 increased risk; current oral contraceptive use, nulliparity, and age ≥30 at first birth were associated with 1.0–1.5 increased risk. Studies varied by measures, reference groups, and adjustment for confounders; effects of multiple risk factors were not considered. Extremely dense breasts and first degree relatives with breast cancer were each associated with ≥2-fold increased breast cancer risk in women age 40–49. Identification of these risk factors may be useful for personalized mammography screening. National Cancer Institute Activities to Promote Research Collaboration supplement (U01CA086076-10S1). Data collection was supported by the National Cancer Institute funded Breast Cancer Surveillance Consortium (BCSC) cooperative agreement (U01CA63740, U01CA86076, U01CA86082, U01CA63736, U01CA70013, U01CA69976, U01CA63731, U01CA70040).
登录
查看更多内容
影响因子：
8
作者：
Anderson, SE;Dallal, GE;Must, A
通讯作者：
Must, A
影响因子：
3.8
作者：
Brown, Linda Morris;Gridley, Gloria;Wu, Anna H.;Falk, Roni T.;Hauptmann, Michael;Kolonel, Laurence N.;West, Dee W.;Nomura, Abraham M. Y.;Pike, Malcolm C.;Hoover, Robert N.;Ziegler, Regina G.
通讯作者：
Ziegler, Regina G.
影响因子：
10.3
作者：
Barlow, William E.;White, Emily;Kerlikowske, Karla
通讯作者：
Kerlikowske, Karla
影响因子：
2.3
作者：
Chang-Claude, J;Eby, N;Becher, H
通讯作者：
Becher, H
DOI：
10.1093/jnci/djj332
发表时间：
2006-09-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Chen, Jinbo;Pee, David;Gail, Mitchell H.
通讯作者：
Gail, Mitchell H.