Vibrational spectroscopy and imaging: applications for tissue engineering.

Vibrational spectroscopy and imaging: applications for tissue engineering.
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DOI:
10.1039/c7an01055a
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发表时间:
2017-10-23
期刊:
The Analyst
影响因子:
--
通讯作者:
Pleshko N
Pleshko N
中科院分区:
其他
文献类型:
--
作者:
Querido W;Falcon JM;Kandel S;Pleshko N

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组织工程(TE)方法努力再生或替换器官或组织。TE构建体的成功开发和随后的整合取决于一系列体外和体内事件,这些事件导致用于植入的最佳构建体。目前广泛使用的用于评价构建体的方法不能在不破坏构建体的情况下提供准确的组成评估。在这篇综述中,我们讨论了振动光谱评估组织工程构建组合物的评价,无论是在开发和植入后的贡献。中红外和近红外范围内的傅里叶变换红外(FTIR)光谱以及拉曼光谱本质上是无标记的,可以是非破坏性的,并提供关于组织化学组成的特定信息。总的来说,我们研究的贡献,振动光谱通过光纤和成像组织工程方法。本文综述了振动光谱在组织工程中的应用。
Tissue engineering (TE) approaches strive to regenerate or replace an organ or tissue. The successful development and subsequent integration of a TE construct is contingent on a series of in vitro and in vivo events that result in an optimal construct for implantation. Current widely used methods for evaluation of constructs are incapable of providing an accurate compositional assessment without destruction of the construct. In this review, we discuss the contributions of vibrational spectroscopic assessment for evaluation of tissue engineered construct composition, both during development and post-implantation. Fourier transform infrared (FTIR) spectroscopy in the mid and near-infrared range, as well as Raman spectroscopy, are intrinsically label free, can be non-destructive, and provide specific information on the chemical composition of tissues. Overall, we examine the contribution that vibrational spectroscopy via fiber optics and imaging have to tissue engineering approaches. We review applications of vibrational spectroscopy for tissue engineering applications.
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