Dysregulated but not decreased salience network activity in schizophrenia.
Dysregulated but not decreased salience network activity in schizophrenia.
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DOI：
10.3389/fnhum.2013.00065
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发表时间：
2013
影响因子：
2.9
通讯作者：
Shergill SS
中科院分区：
文献类型：
--
作者：
White TP;Gilleen J;Shergill SS
对环境刺激显著性的有效估计是适应性行为的基础，而相关的异常被认为会破坏精神分裂症的理性思维过程。利用功能性磁共振成像（fMRI）观察到包括双侧额岛皮层（FIC）和背前扣带皮层（dACC）在内的一个网络对显著刺激做出反应。为了验证精神分裂症患者的显着性网络（SN）活动受情境相关刺激的区别调节程度低于健康个体的假设，我们收集了20名精神分裂症患者和13名匹配对照者在执行修改后的货币激励延迟（MID）任务时的fMRI数据。在定量识别了具有代表性的空间成分FIC和dACC特征后，进行了两个主要分析。首先，通过测量对试验结果的反应来评估显着性对SN活性的调节。利用空间独立分量分析（ICA），将一级一般线性模型应用于SN活动的个体特异性时间过程。该分析揭示了在试验结果中，最适合的FIC成分活性的显著性-表现-组相互作用，即健康个体而非精神分裂症个体在高显著性试验中对击中和未击中的反应比在低显著性试验中表现出更大的差异。第二个分析旨在确定在实验期间，研究组之间的SN分量振幅是否存在差异。对反向投影、百分比信号变化比例的SN分量图像进行的独立样本t检验重要地表明，在整个数据集上，各组SN表达的总体幅度没有差异。这些发现为妄想思维形成的机制概念框架提供了生理上的支持。
Effective estimation of the salience of environmental stimuli underlies adaptive behavior, while related aberrance is believed to undermine rational thought processes in schizophrenia. A network including bilateral frontoinsular cortex (FIC) and dorsal anterior cingulate cortex (dACC) has been observed to respond to salient stimuli using functional magnetic resonance imaging (fMRI). To test the hypothesis that activity in this salience network (SN) is less discriminately modulated by contextually-relevant stimuli in schizophrenia than in healthy individuals, fMRI data were collected in 20 individuals with schizophrenia and 13 matched controls during performance of a modified monetary incentive delay (MID) task. After quantitatively identifying spatial components representative of the FIC and dACC features of the SN, two principal analyses were conducted. In the first, modulation of SN activity by salience was assessed by measuring response to trial outcome. First-level general linear models were applied to individual-specific time-courses of SN activity identified using spatial independent component analysis (ICA). This analysis revealed a significant salience-by-performance-by-group interaction on the best-fit FIC component's activity at trial outcome, whereby healthy individuals but not individuals with schizophrenia exhibited greater distinction between the response to hits and misses in high salience trials than in low salience trials. The second analysis aimed to ascertain whether SN component amplitude differed between the study groups over the duration of the experiment. Independent-samples T-tests on back-projected, percent-signal-change scaled SN component images importantly showed that the groups did not differ in the overall amplitude of SN expression over the entire dataset. These findings of dysregulated but not decreased SN activity in schizophrenia provide physiological support for mechanistic conceptual frameworks of delusional thought formation.
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影响因子：
5.7
作者：
Luckhoo, H.;Hale, J. R.;Stokes, M. G.;Nobre, A. C.;Morris, P. G.;Brookes, M. J.;Woolrich, M. W.
通讯作者：
Woolrich, M. W.
影响因子：
25
作者：
Maia, Tiago V.;Frank, Michael J.
通讯作者：
Frank, Michael J.
影响因子：
15.9
作者：
Redgrave, P;Prescott, TJ;Gurney, K
通讯作者：
Gurney, K
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.7
作者：
Calhoun VD;Liu J;Adali T
通讯作者：
Adali T