Quantifying MCMC exploration of phylogenetic tree space.
Quantifying MCMC exploration of phylogenetic tree space.
复制标题
量化系统发育树空间的MCMC探索。
DOI:
10.1093/sysbio/syv006
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发表时间:
2015-05
影响因子:
6.5
通讯作者:
Matsen FA 4th
中科院分区:
文献类型:
--
作者:
Whidden C;Matsen FA 4th
In order to gain an understanding of the effectiveness of phylogenetic Markov chain Monte Carlo (MCMC), it is important to understand how quickly the empirical distribution of the MCMC converges to the posterior distribution. In this article, we investigate this problem on phylogenetic tree topologies with a metric that is especially well suited to the task: the subtree prune-and-regraft (SPR) metric. This metric directly corresponds to the minimum number of MCMC rearrangements required to move between trees in common phylogenetic MCMC implementations. We develop a novel graph-based approach to analyze tree posteriors and find that the SPR metric is much more informative than simpler metrics that are unrelated to MCMC moves. In doing so, we show conclusively that topological peaks do occur in Bayesian phylogenetic posteriors from real data sets as sampled with standard MCMC approaches, investigate the efficiency of Metropolis-coupled MCMC (MCMCMC) in traversing the valleys between peaks, and show that conditional clade distribution (CCD) can have systematic problems when there are multiple peaks.
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影响因子:
1.1
作者:
Hein, J;Jiang, T;Zhang, KZ
通讯作者:
Zhang, KZ
影响因子:
3.9
作者:
Garey, JR;Near, TJ;Nadler, SA
通讯作者:
Nadler, SA
影响因子:
10.7
作者:
Drummond, Alexei J.;Suchard, Marc A.;Rambaut, Andrew
通讯作者:
Rambaut, Andrew
影响因子:
3.9
作者:
HASEGAWA, M;KISHINO, H;YANO, TA
通讯作者:
YANO, TA
影响因子:
3
作者:
KRUSKAL, JB
通讯作者:
KRUSKAL, JB