Impaired body-centred sensorimotor transformations in congenitally deaf people.
Impaired body-centred sensorimotor transformations in congenitally deaf people.
复制标题
先天性聋人以身体为中心的感觉运动转变受损
DOI：
10.1093/braincomms/fcac148
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
先天性耳聋改变了个体与环境的日常互动，改变了对外部世界的基本感知。先天性耳聋如何塑造内部和外部世界之间的界面仍然知之甚少。为了有效地与外部世界互动，外部目标物体的视觉空间表征需要有效地转化为参照身体的感觉运动表征。在这里，我们检验了以自我为中心的身体为中心的感觉运动转化在先天性耳聋中受损的假设。与这一假设一致，我们发现先天性耳聋导致了自我中心判断的障碍，将外部物体与内部身体联系起来。这些损伤是由于身体中心感觉运动转换本身的缺陷，而不是自我中心位置的视觉空间表征的保真度降低。在神经层面，我们首先在先天失聪的参与者和听力控制的参与者中复制了先前充分记录的额顶叶网络在自我中心处理中的关键参与。然而，单独的神经活动强度和额顶叶网络内的网络连通性都不能解释自我中心的表现差异。相反，任务正性额顶叶网络与任务负性默认模式网络之间的网络间连通性与自我中心表现显著相关：它们之间的交叉对话越多，自我中心判断越差。因此，失聪组自我中心表现受损与额顶叶网络与默认模式网络之间网络间连通性增加以及默认模式网络内网络内连通性降低有关。观察了先天性耳聋患者在自我中心加工过程中的诱发神经活动和休息时的内在神经活动的神经网络动态变化。因此，我们的研究结果不仅证明了任务正神经网络和负神经网络之间的最佳网络配置，这些网络是协调一致的以身体为中心的感觉运动转换的基础，而且还揭示了聋人在日常生活中经历的各种迄今无法解释的感觉引导运动困难的关键原因（即以身体为中心的感觉运动转换受损）。Li等人研究了聋人空间参考框架系统潜在改变的认知和神经机制，发现早期听觉剥夺损害了自我中心加工，这与诱发和内在神经活动中任务积极网络和任务消极网络之间异常增加的串扰有关。
Congenital deafness modifies an individual’s daily interaction with the environment and alters the fundamental perception of the external world. How congenital deafness shapes the interface between the internal and external worlds remains poorly understood. To interact efficiently with the external world, visuospatial representations of external target objects need to be effectively transformed into sensorimotor representations with reference to the body. Here, we tested the hypothesis that egocentric body-centred sensorimotor transformation is impaired in congenital deafness. Consistent with this hypothesis, we found that congenital deafness induced impairments in egocentric judgements, associating the external objects with the internal body. These impairments were due to deficient body-centred sensorimotor transformation per se, rather than the reduced fidelity of the visuospatial representations of the egocentric positions. At the neural level, we first replicated the previously well-documented critical involvement of the frontoparietal network in egocentric processing, in both congenitally deaf participants and hearing controls. However, both the strength of neural activity and the intra-network connectivity within the frontoparietal network alone could not account for egocentric performance variance. Instead, the inter-network connectivity between the task-positive frontoparietal network and the task-negative default-mode network was significantly correlated with egocentric performance: the more cross-talking between them, the worse the egocentric judgement. Accordingly, the impaired egocentric performance in the deaf group was related to increased inter-network connectivity between the frontoparietal network and the default-mode network and decreased intra-network connectivity within the default-mode network. The altered neural network dynamics in congenital deafness were observed for both evoked neural activity during egocentric processing and intrinsic neural activity during rest. Our findings thus not only demonstrate the optimal network configurations between the task-positive and -negative neural networks underlying coherent body-centred sensorimotor transformations but also unravel a critical cause (i.e. impaired body-centred sensorimotor transformation) of a variety of hitherto unexplained difficulties in sensory-guided movements the deaf population experiences in their daily life. Li et al. investigate the cognitive and neural mechanisms underlying the potentially altered spatial reference frame system in deaf people and reveal that early auditory deprivation impairs egocentric processing, which is associated with an abnormally increased cross-talk between task-positive and task-negative networks, for both evoked and intrinsic neural activity.
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影响因子：
1.5
作者：
Conway CM;Karpicke J;Anaya EM;Henning SC;Kronenberger WG;Pisoni DB
通讯作者：
Pisoni DB
影响因子：
64.8
作者：
CARAMAZZA, A;HILLIS, AE
通讯作者：
HILLIS, AE
DOI：
10.3758/bf03211221
发表时间：
1976-01-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
CORBALLIS, MC;ZBRODOFF, J;ROLDAN, CE
通讯作者：
ROLDAN, CE
DOI：
10.1088/1742-5468/2008/10/p10008
发表时间：
2008-10-01
影响因子：
2.4
作者：
Blondel, Vincent D.;Guillaume, Jean-Loup;Lefebvre, Etienne
通讯作者：
Lefebvre, Etienne
影响因子：
5.3
作者：
Bavelier, D;Brozinsky, C;Liu, GY
通讯作者：
Liu, GY