Decomposing attention-deficit/hyperactivity disorder (ADHD)-related effects in response speed and variability.
Decomposing attention-deficit/hyperactivity disorder (ADHD)-related effects in response speed and variability.
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DOI：
10.1037/a0029936
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发表时间：
2012-11
期刊：
影响因子：
2.4
通讯作者：
Nigg JT
中科院分区：
文献类型：
--
作者：
Karalunas SL;Huang-Pollock CL;Nigg JT
Slow and variable reaction times (RTs) on fast tasks are such a prominent feature of Attention Deficit Hyperactivity Disorder (ADHD) that any theory must account for them. However, this has proven difficult because the cognitive mechanisms responsible for this effect remain unexplained. Although speed and variability are typically correlated, it is unclear whether single or multiple mechanisms are responsible for group differences in each. RTs are a result of several semi-independent processes, including stimulus encoding, rate of information processing, speed-accuracy trade-offs, and motor response, which have not been previously well characterized. A diffusion model was applied to RTs from a forced-choice RT paradigm in two large, independent case-control samples (NCohort 1= 214 and N Cohort 2=172). The decomposition measured three validated parameters that account for the full RT distribution, and assessed reproducibility of ADHD effects. In both samples, group differences in traditional RT variables were explained by slow information processing speed, and unrelated to speed-accuracy trade-offs or non-decisional processes (e.g. encoding, motor response). RT speed and variability in ADHD may be explained by a single information processing parameter, potentially simplifying explanations that assume different mechanisms are required to account for group differences in the mean and variability of RTs.
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通讯作者：
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DOI：
10.1073/pnas.1115365109
发表时间：
2012-04-24
影响因子：
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Nigg, Joel T.
DOI：
10.1073/pnas.0805903105
发表时间：
2008-11-11
影响因子：
11.1
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