Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside.
Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside.
复制标题
GM1 神经节苷脂致敏诱导的轴突吉兰-巴利综合征动物模型。
DOI：
10.1002/ana.1012.abs
复制
发表时间：
2001
影响因子：
11.2
通讯作者：
K. Hirata
中科院分区：
文献类型：
--
作者：
N. Yuki;M. Yamada;M. Koga;M. Odaka;K. Susuki;Y. Tagawa;S. Ueda;T. Kasama;A. Ohnishi;S. Hayashi;H. Takahashi;M. Kamijo;K. Hirata
一些人在接受牛脑神经节苷脂后发展为格林-巴利综合征的轴突形式。用神经节苷脂混合物致敏后，所有注射的一组家兔均出现高抗GM 1 IgG抗体滴度、急性发作的四肢无力和双相病程。周围神经的病理结果显示主要的沃勒样变性，既没有淋巴细胞浸润，也没有脱髓鞘。免疫组化结果显示，IgG主要分布在前根的轴突上，GM 1主要分布在周围神经的轴突上。用纯化的GM 1致敏也诱导轴突神经病变，表明GM 1是混合物中的免疫原。已经建立了人轴突格林-巴利综合征模型，该模型使用牛脑神经节苷脂混合物或分离的GM 1接种。该模型可能有助于阐明该综合征的分子发病机制，并开发新的治疗方法。
Some humans develop the axonal form of Guillain-Barre syndrome after receiving bovine brain ganglioside. On sensitization with the ganglioside mixture, all of a group of rabbits injected developed high anti-GM1 IgG antibody titers, flaccid limb weakness of acute onset, and a monophasic illness course. Pathological findings for the peripheral nerves showed predominant Wallerian-like degeneration, with neither lymphocytic infiltration nor demyelination. IgG was deposited on the axons of the anterior roots, and GM1 was proved to be present on the axons of peripheral nerves. Sensitization with purified GM1 also induced axonal neuropathy, indicating that GM1 was the immunogen in the mixture. A model of human axonal Guillain-Barre syndrome has been established that uses inoculation with a bovine brain ganglioside mixture or isolated GM1. This model may help to clarify the molecular pathogenesis of the syndrome and to develop new treatments for it.
神经节苷脂样部分在周围神经中的分布。
DOI：
10.1093/brain/122.3.449
发表时间：
1999
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Sheikh,KA;Deerinck,TJ;Ellisman,MH;Griffin,JW
通讯作者：
Griffin,JW
影响因子：
14.5
作者：
GRIFFIN, JW;LI, CY;ASBURY, AK
通讯作者：
ASBURY, AK