On ERPs detection in disorders of consciousness rehabilitation.
On ERPs detection in disorders of consciousness rehabilitation.
复制标题
DOI：
10.3389/fnhum.2013.00775
复制
发表时间：
2013
影响因子：
2.9
通讯作者：
Mattia D
中科院分区：
文献类型：
--
作者：
Risetti M;Formisano R;Toppi J;Quitadamo LR;Bianchi L;Astolfi L;Cincotti F;Mattia D
意识障碍（DOC）如植物状态（VS）和最小意识状态（MCS）是以缺乏或间歇性行为反应为特征的临床病症。事件相关电位（ERP）等参数的神经生理学监测可能是随访这些患者在康复阶段临床进展的第一步。11例经JFK昏迷恢复量表修订版（CRS-R）诊断为VS（n = 8）和MCS（n = 3）的患者在提供3刺激听觉oddball范式期间进行头皮EEG记录，该范式包括标准、异常音调和作为新刺激的受试者自己的名字（SON），在被动和主动条件下施用。4例患者显示通过CRS-R检测到的临床状态变化（即，从VS移动到MCS），进行第二次EEG记录会话。除1例（缺氧病因）外，所有患者在被动状态下均出现错配负波（MMN）和新奇P300（nP 3）等ERP成分。当患者被要求计算新的刺激（主动条件），nP 3分量显示出显着增加的幅度（p = 0.009）和更广泛的地形分布相对于被动听，只有在MCS。在4名患者中的2名患者中，他们在从VS过渡到MCS的过程中进行了第二次记录，被动聆听SON刺激引起的nP 3分量显示出显著的振幅增加（p < 0.05）。最相关的是，在每例患者和所有记录会话中获得的活动条件下的nP 3分量的振幅与每次EEG记录前给予的CRS-R的总分（p = 0.004）和听觉子评分（p < 0.00001）呈显著正相关。因此，目前的研究结果证实了ERP监测DOC患者的价值，以调查残留的无意识和有意识的认知功能。
Disorders of Consciousness (DOC) like Vegetative State (VS), and Minimally Conscious State (MCS) are clinical conditions characterized by the absence or intermittent behavioral responsiveness. A neurophysiological monitoring of parameters like Event-Related Potentials (ERPs) could be a first step to follow-up the clinical evolution of these patients during their rehabilitation phase. Eleven patients diagnosed as VS (n = 8) and MCS (n = 3) by means of the JFK Coma Recovery Scale Revised (CRS-R) underwent scalp EEG recordings during the delivery of a 3-stimuli auditory oddball paradigm, which included standard, deviant tones and the subject own name (SON) presented as a novel stimulus, administered under passive and active conditions. Four patients who showed a change in their clinical status as detected by means of the CRS-R (i.e., moved from VS to MCS), were subjected to a second EEG recording session. All patients, but one (anoxic etiology), showed ERP components such as mismatch negativity (MMN) and novelty P300 (nP3) under passive condition. When patients were asked to count the novel stimuli (active condition), the nP3 component displayed a significant increase in amplitude (p = 0.009) and a wider topographical distribution with respect to the passive listening, only in MCS. In 2 out of the 4 patients who underwent a second recording session consistently with their transition from VS to MCS, the nP3 component elicited by passive listening of SON stimuli revealed a significant amplitude increment (p < 0.05). Most relevant, the amplitude of the nP3 component in the active condition, acquired in each patient and in all recording sessions, displayed a significant positive correlation with the total scores (p = 0.004) and with the auditory sub-scores (p < 0.00001) of the CRS-R administered before each EEG recording. As such, the present findings corroborate the value of ERPs monitoring in DOC patients to investigate residual unconscious and conscious cognitive function.
登录
查看更多内容
影响因子：
9.9
作者：
Cruse, D.;Chennu, S.;Owen, A. M.
通讯作者：
Owen, A. M.
影响因子：
4.7
作者：
Babiloni, Claudio;Sara, Marco;Rossini, Paolo Maria
通讯作者：
Rossini, Paolo Maria
影响因子：
2.4
作者：
Goldfine, Andrew M.;Schiff, Nicholas D.
通讯作者：
Schiff, Nicholas D.
影响因子：
9.9
作者：
Estraneo, Anna;Moretta, Pasquale;Trojano, Luigi
通讯作者：
Trojano, Luigi
影响因子：
4.7
作者：
Fischer, Catherine;Luaute, Jacques;Morlet, Dominique
通讯作者：
Morlet, Dominique