Aquaglyceroporins: generalized metalloid channels.
Aquaglyceroporins: generalized metalloid channels.
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DOI：
10.1016/j.bbagen.2013.11.021
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发表时间：
2014-05
影响因子：
3
通讯作者：
Rosen, Barry P.
中科院分区：
文献类型：
--
作者：
Mukhopadhyay, Rita;Bhattacharjee, Hiranmoy;Rosen, Barry P.
水通道蛋白(Aquaporins，AQPs)是跨膜通道蛋白超家族的一员，广泛存在于生命的各个领域。它们可分为两大亚类：i)正统水通道蛋白，它们是水特有的通道；ii)水甘油通道蛋白，它允许水、非极性溶质，如尿素或甘油，活性氧物种过氧化氢，以及气体，如氨，二氧化碳和一氧化氮，以及本综述中描述的类金属物质的运输。本文综述了AQP通道引导类金属物质双向进出细胞的主要发现。As(OH)3和Sb(OH)3表现为甘油的无机分子模拟物，这一性质允许它们通过AQP通道。植物水通道蛋白还允许硼和硅分别作为它们的羟基酸、硼酸(B(OH)3)和正硅酸(Si(OH)4)通过。遗传分析表明，德国酸(GeO2)也是底物。As(III)、Sb(III)和Ge(IV)是有毒类金属，而B(III)和Si(IV)是高等植物所必需的元素。水通道蛋白对环境类金属的吸收使人们了解：(1)砷等有毒元素如何进入食物链；(2)含砷和锑的药物在治疗某些形式的白血病和治疗致病原生动物引起的疾病的化疗中的输送；(3)通过对食用植物进行基因改造以排除砷，同时仍积累硼和硅，使它们变得更安全的可能性。
Aquaporins (AQPs), members of a superfamily of transmembrane channel proteins, are ubiquitous in all domains of life. They fall into a number of branches that can be functionally categorized into two major sub-groups: i) orthodox aquaporins, which are water-specific channels, and ii) aquaglyceroporins, which allow the transport of water, non-polar solutes, such as urea or glycerol, the reactive oxygen species hydrogen peroxide, and gases such as ammonia, carbon dioxide and nitric oxide and, as described in this review, metalloids. This review summarizes the key findings that AQP channels conduct bidirectional movement of metalloids into and out of cells. As(OH)3 and Sb(OH)3 behave as inorganic molecular mimics of glycerol, a property that allows their passage through AQP channels. Plant AQPs also allow the passage of boron and silicon as their hydroxyacids, boric acid (B(OH)3) and orthosilicic acid (Si(OH)4), respectively. Genetic analysis suggests that germanic acid (GeO2) is also a substrate. While As(III), Sb(III) and Ge(IV) are toxic metalloids, borate (B(III)) and silicate (Si(IV)) are essential elements in higher plants. The uptake of environmental metalloids by aquaporins provides an understanding of (i) how toxic elements such as arsenic enter the food chain; (ii) the delivery of arsenic and antimony containing drugs in the treatment of certain forms of leukemia and chemotherapy of diseases caused by pathogenic protozoa; and (iii) the possibility that food plants such as rice could be made safer by genetically modifying them to exclude arsenic while still accumulating boron and silicon.
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影响因子：
5.4
作者：
Bienert GP;Thorsen M;Schüssler MD;Nilsson HR;Wagner A;Tamás MJ;Jahn TP
通讯作者：
Jahn TP
影响因子：
4.2
作者：
Abernathy, CO;Thomas, DJ;Calderon, RL
通讯作者：
Calderon, RL
DOI：
10.1073/pnas.0908108106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Carbrey, Jennifer M.;Song, Linhua;Mukhopadhyay, Rita
通讯作者：
Mukhopadhyay, Rita
影响因子：
2
作者：
Docampo, R;Moreno, SNJ
通讯作者：
Moreno, SNJ
影响因子：
4.8
作者：
Gourbal, B;Sonuc, N;Mukhopadhyay, R
通讯作者：
Mukhopadhyay, R