Plasma Nervonic Acid Is a Potential Biomarker for Major Depressive Disorder: A Pilot Study.
Plasma Nervonic Acid Is a Potential Biomarker for Major Depressive Disorder: A Pilot Study.
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DOI：
10.1093/ijnp/pyx089
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发表时间：
2018-03-01
期刊：
影响因子：
--
通讯作者：
Kato T
中科院分区：
文献类型：
--
作者：
Kageyama Y;Kasahara T;Nakamura T;Hattori K;Deguchi Y;Tani M;Kuroda K;Yoshida S;Goto YI;Inoue K;Kato T
由于目前还没有可用的生物标志物，因此迫切需要诊断抑郁症、双相情感障碍和精神分裂症的生物标志物。我们使用液相色谱-飞行时间质谱法对无药物的重度抑郁症患者（n=9）、双相情感障碍患者（n=6）、精神分裂症患者（n=17）和匹配的健康对照组（n=19）（队列1）的血浆样本进行了全面的代谢组学分析。发现2种代谢物的诊断效果显著：神经酸和可的松，其中神经酸的变化最显著。在队列2中验证了结果的重现性和精神药物对神经酸的影响，队列2是一个独立的样本集，使用气相色谱飞行时间质谱法对接受药物治疗的患者[重度抑郁症（n=45），双相情感障碍（n=71），精神分裂症（n=115）]和对照组（n=90）进行了验证。与对照组和队列1中的双相情感障碍患者相比，重度抑郁症患者的神经酸水平升高在独立样本集（队列2）中重复。在队列2中，与精神分裂症患者相比，重度抑郁症患者的血浆神经酸水平也升高。在队列2中，与重度抑郁症患者缓解状态和双相情感障碍患者抑郁状态的水平相比，重度抑郁症患者抑郁状态的神经酸水平升高。这些结果表明，血浆神经酸是一个很好的候选生物标志物抑郁症的抑郁状态。
Diagnostic biomarkers of major depressive disorder, bipolar disorder, and schizophrenia are urgently needed, because none are currently available. We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with major depressive disorder (n=9), bipolar disorder (n=6), schizophrenia (n=17), and matched healthy controls (n=19) (cohort 1) using liquid chromatography time-of-flight mass spectrometry. A significant effect of diagnosis was found for 2 metabolites: nervonic acid and cortisone, with nervonic acid being the most significantly altered. The reproducibility of the results and effects of psychotropic medication on nervonic acid were verified in cohort 2, an independent sample set of medicated patients [major depressive disorder (n=45), bipolar disorder (n=71), schizophrenia (n=115)], and controls (n=90) using gas chromatography time-of-flight mass spectrometry. The increased levels of nervonic acid in patients with major depressive disorder compared with controls and patients with bipolar disorder in cohort 1 were replicated in the independent sample set (cohort 2). In cohort 2, plasma nervonic acid levels were also increased in the patients with major depressive disorder compared with the patients with schizophrenia. In cohort 2, nervonic acid levels were increased in the depressive state in patients with major depressive disorder compared with the levels in the remission state in patients with major depressive disorder and the depressive state in patients with bipolar disorder. These results suggested that plasma nervonic acid is a good candidate biomarker for the depressive state of major depressive disorder.
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影响因子：
6.6
作者：
Altamura, A. Carlo;Buoli, Massimiliano;Quarantini, Francesco Zanelli
通讯作者：
Quarantini, Francesco Zanelli
影响因子：
6.7
作者：
Drancourt, N.;Etain, B.;Bellivier, F.
通讯作者：
Bellivier, F.
影响因子：
4.4
作者：
Cai, Hua-Lin;Li, Huan-De;Ye, Hai-Sen
通讯作者：
Ye, Hai-Sen
DOI：
10.1073/pnas.1114410109
发表时间：
2012-02-14
影响因子：
11.1
作者：
Dallmann, Robert;Viola, Antoine U.;Brown, Steven A.
通讯作者：
Brown, Steven A.
影响因子：
16.6
作者：
Amminger GP;Schäfer MR;Schlögelhofer M;Klier CM;McGorry PD
通讯作者：
McGorry PD