Cancer risk in first- and second-degree relatives of men with poor semen quality.
Cancer risk in first- and second-degree relatives of men with poor semen quality.
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DOI：
10.1016/j.fertnstert.2016.05.021
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发表时间：
2016-09-01
影响因子：
6.7
通讯作者：
Hotaling JM
中科院分区：
文献类型：
--
作者：
Anderson RE;Hanson HA;Patel DP;Johnstone E;Aston KI;Carrell DT;Lowrance WT;Smith KR;Hotaling JM
通过评估家庭成员的精液质量和癌症风险，进一步描述男性不育与健康风险的关系。回顾性队列研究。不适用。通过 UPDB 确定了总共 12,889 名接受 SA 的男性和 12,889 名具有一级亲属 (FDR) 数据的可生育对照受试者 (n = 130,689)，以及 8,032 名接受 SA 的男性和 8,032 名具有完整二级亲属 (SDR) 数据的可生育对照受试者 (n = 247,204)。匹配相同数量的可育群体对照受试者。没有任何。 FDR 和 SDR 中的成人全部位癌、睾丸癌、甲状腺癌、乳腺癌、前列腺癌、黑色素瘤、膀胱癌、卵巢癌和肾癌诊断。与育龄人群对照受试者的 FDR 相比，SA 男性的 FDR 患睾丸癌的风险增加 52%。根据任何精液参数，SDR 的睾丸癌风险没有显着差异。与有生育能力的人群对照受试者相比，无精子症男性的 FDR 和 SDR 患甲状腺癌的风险显着增加。这些数据表明男性不育症与亲属中特定的癌症风险之间存在联系。这凸显了这两种疾病之间可能存在共同的生物学机制、环境因素的暴露以及生育力低下的男性及其亲属的遗传和/或表观遗传负担水平的增加，这些可能与癌症风险相关。
To further characterize the association of male infertility with health risks by evaluating semen quality and cancer risk in family members. Retrospective, cohort study. Not applicable. A total of 12,889 men undergoing SA and 12,889 fertile control subjects that had first-degree relative (FDR) data (n = 130,689) and 8,032 men with SA and 8,032 fertile control subjects with complete second-degree relative (SDR) data (n = 247,204) were identified through the UPDB. An equal number of fertile population control subjects were matched. None. Adult all-site, testicular, thyroid, breast, prostate, melanoma, bladder, ovarian, and kidney cancer diagnoses in FDRs and SDRs. The FDRs of men with SA had a 52% increased risk of testicular cancer compared with the FDRs of fertile population control subjects. There was no significant difference in testicular cancer risk for the SDRs based on any of the semen parameters. The FDRs and SDRs of azoospermic men had a significantly increased risk of thyroid cancer compared with fertile population control subjects. These data suggest a link between male infertility and selected cancer risk in relatives. This highlights the possibilities of shared biologic mechanisms between the two diseases, exposure to environmental factors, and an increased level of genetic and/or epigenetic burden in subfertile men and their relatives that may be associated with risk of cancer.
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影响因子：
2.5
作者：
Mukherjee S;Ridgeway AD;Lamb DJ
通讯作者：
Lamb DJ
错配修复基因的常见变异与精子 DNA 损伤和男性不育风险增加相关
影响因子：
9.3
作者：
Ji G;Long Y;Zhou Y;Huang C;Gu A;Wang X
通讯作者：
Wang X
影响因子：
8.4
作者：
Sonneveld, DJA;Sleijfer, DT;Hoekstra, HJ
通讯作者：
Hoekstra, HJ
DOI：
10.1073/pnas.1635054100
发表时间：
2003-10-14
影响因子：
11.1
作者：
Schultz, N;Hamra, FK;Garbers, DL
通讯作者：
Garbers, DL
影响因子：
105.7
作者：
Jacobsen, R;Bostofte, E;Moller, H
通讯作者：
Moller, H