Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging.
Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging.
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DOI：
10.1016/j.neuroimage.2018.10.023
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发表时间：
2019-01-15
期刊：
影响因子：
5.7
通讯作者：
Frangou S
中科院分区：
文献类型：
--
作者：
Sprooten E;O'Halloran R;Dinse J;Lee WH;Moser DA;Doucet GE;Goodman M;Krinsky H;Paulino A;Rasgon A;Leibu E;Balchandani P;Inglese M;Frangou S
皮质内髓鞘是神经元同步性和可塑性的关键决定因素，这些因素支撑着最佳的大脑功能。磁共振成像(MRI)方便了皮质内髓鞘的检查，但在方法学上存在挑战。在这里，我们描述了一种使用超高场MRI对人脑皮质内髓鞘进行活体研究的全脑方法。25名健康成年人在7特斯拉磁共振扫描仪上使用扩散加权成像和针对皮质内髓鞘对比优化的T1加权序列进行成像。使用自动化管道，从148个皮质区域中的每个区域提取20个深度水平的T1值。在每个皮质区域，T1值被用来推断髓鞘浓度，并构建一个非线性指数来衡量髓鞘在皮质带上的空间分布。研究了髓鞘浓度和非线性指数与其他神经解剖学特征的关系。五名多发性硬化症患者也使用与阳性对照相同的方案进行评估。皮质内T1值在皮质深度的50%到75%之间略有平坦后，在大脑外表面和灰白质边界之间降低。前额叶、扣带回和岛叶皮质的高阶区域的非线性指数高于感觉运动区。在所有地区，T1值与非线性指数呈正相关(p<；10−5)。T1值(P<；10−5)和非线性指数(P<；10−15)均与皮质厚度相关。较高的髓鞘浓度，但仅在最深的皮质水平与皮质下分数各向异性增加相关(P=0.05)。我们展示了一种自动的、全脑的方法来进行皮质内髓鞘组织的深度相关检查。所提取的度量、T1值和非线性指数具有跨皮质区域的特征模式，并且与厚度和潜在的白质微结构相关联。
Intracortical myelin is a key determinant of neuronal synchrony and plasticity that underpin optimal brain function. Magnetic resonance imanging (MRI) facilitiates the examination of intracortical myelin but presents with methodological challenges. Here we describe a whole-brain approach for the in vivo investigation of intracortical myelin in the human brain using ultra-high field MRI. Twenty-five healthy adults were imaged in a 7 Tesla MRI scanner using diffusion-weighted imaging and a T1-weighted sequence optimized for intracortical myelin contrast. Using an automated pipeline, T1 values were extracted at 20 depth-levels from each of 148 cortical regions. In each cortical region, T1 values were used to infer myelin concentration and to construct a non-linearity index as a measure the spatial distribution of myelin across the cortical ribbon. The relationship of the myelin concertation and non-linearity index with other neuroanatomical properties were investigated. Five patients with multiple sclerosis were also assessed using the same protocol as positive controls. Intracortical T1 values decreased between the outer brain surface and the gray-white matter boundary following a slope that showed a slight leveling between 50% and 75% of cortical depth. Higher order regions in the prefrontal, cingulate cortex and insular cortices, displayed higher non-linearity indices than sensorimotor regions. Across all regions, there was a positive association between T1 values and non-linearity indices (p < 10−5). Both T1 values (P < 10−5) and non-linearity indices (P < 10−15) were associated with cortical thickness. Higher myelin concentration but only in the deepest cortical levels was associated with increased subcortical fractional anisotropy (P=0.05). We demonstrate the use of an automatic, whole-brain method to perform depth-dependent examination of intracortical myelin organization. The extracted metrics, T1 values and the non-linearity index, have characteristic patterns across cortical regions, and are associated with thickness and underlying white matter microstructure.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
5.7
作者：
Dinse, J.;Haertwich, N.;Bazin, P. -L.
通讯作者：
Bazin, P. -L.
DOI：
10.1177/1073858413504465
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Fields RD;Araque A;Johansen-Berg H;Lim SS;Lynch G;Nave KA;Nedergaard M;Perez R;Sejnowski T;Wake H
通讯作者：
Wake H
影响因子：
5.7
作者：
Marques, Jose P.;Kober, Tobias;Gruetter, Rolf
通讯作者：
Gruetter, Rolf
影响因子：
10.6
作者：
Bazin, Pierre-Louis;Pham, Dzung L.
通讯作者：
Pham, Dzung L.