Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging.
Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging.
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DOI：
10.1002/jmri.21676
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发表时间：
2009-03
影响因子：
4.4
通讯作者：
Grossman, Robert I.
中科院分区：
文献类型：
--
作者：
Haacke, E. Mark;Makki, Malek;Ge, Yulin;Maheshwari, Megha;Sehgal, Vivek;Hu, Jiani;Selvan, Madeswaran;Wu, Zhen;Latif, Zahid;Xuan, Yang;Khan, Omar;Garbern, James;Grossman, Robert I.
探讨磁敏感加权成像（SWI）中所见的各种形式的假定铁沉积是否会导致一组不同于常规MR成像的多发性硬化（MS）病变特征。27例临床确诊的MS患者使用磁共振成像进行脑部扫描，包括：对比前后T1加权、T2加权、FLAIR和1.5T、3T和4T的SWI。在每个成像序列中分别识别MS病变。使用SWI过滤相位图像重新评价SWI中识别的病变的铁含量。SWI发现了多种新的病变特征，并将其分为6种类型。共有75个病灶仅通过常规成像观察到，143个病灶仅通过SWI观察到，204个病灶通过两者观察到。根据铁定量测量，建立了信号强度和铁含量（相位）之间的适度线性相关性。脑内铁沉积量可作为不同MS病变特征的替代生物标志物。SWI显示了许多传统方法遗漏的病变和六种不同的病变特征。SWI在识别MS病变以及基底节和枕丘脑中铁的存在方面特别有效。
To investigate whether the variable forms of putative iron deposition seen with susceptibility weighted imaging (SWI) will lead to a set of multiple sclerosis (MS) lesion characteristics different than that seen in conventional MR imaging. Twenty-seven clinically definite MS patients underwent brain scans using magnetic resonance imaging including: pre- and post-contrast T1-weighted, T2-weighted, FLAIR, and SWI at 1.5T, 3T and 4T. MS lesions were identified separately in each imaging sequence. Lesions identified in SWI were re-evaluated for their iron content using the SWI filtered phase images. There were a variety of new lesion characteristics identified by SWI and these were classified into six types. A total of 75 lesions were seen only with conventional imaging, 143 only with SWI and 204 by both. From the iron quantification measurements, a moderate linear correlation between signal intensity and iron content (phase) was established. The amount of iron deposition in the brain may serve as a surrogate biomarker for different MS lesion characteristics. SWI showed many lesions missed by conventional methods and six different lesion characteristics. SWI was particularly effective at recognizing the presence of iron in MS lesions and in the basal ganglia and pulvinar thalamus.
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影响因子：
2.5
作者：
MacKay, A;Laule, C;M채dler, B
通讯作者：
M채dler, B
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
DOI：
10.1196/annals.1306.021
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
LeVine, SM;Chakrabarty, A
通讯作者：
Chakrabarty, A
影响因子：
5.6
作者：
Filippi, Massimo;Rocca, Maria A;Rovaris, Marco
通讯作者：
Rovaris, Marco
影响因子：
3.3
作者：
DWORK, AJ;SCHON, EA;HERBERT, J
通讯作者：
HERBERT, J