Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy.
Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy.
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DOI：
10.1186/s12951-021-01001-4
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发表时间：
2021-08-23
影响因子：
10.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Cai X;Wang KN;Ma W;Yang Y;Chen G;Fu H;Cui C;Yu Z;Wang X
由于传统光敏剂的水溶性差、活性氧（ROS）产生效率低、暗细胞毒性大以及在NIR区域吸收弱，开发用于深层组织成像和有效光动力学疗法（PDT）的新型光敏剂仍然是一个挑战。本文设计了具有聚集诱导发射（AIE）特征、高光诱导活性氧产生效率、双光子激发和靶向能力的环化铱（III）配合物（Ir），并将其进一步封装到生物相容性纳米颗粒（NP）中。Ir-NPs在体外可干扰氧化还原稳态，导致线粒体功能障碍和细胞凋亡。重要的是，体内实验表明，Ir-NPs具有明显的肿瘤靶向性，良好的抗肿瘤效果，并且系统暗毒性低。此外，Ir-NP还可以作为双光子成像剂用于深层组织生物成像，穿透深度高达300 μm。这项工作提出了一个有前途的策略，设计一个多功能的Ir-NPs的生物成像和PDT的临床应用。在线版本包含补充材料，可通过10.1186/s12951-021-01001-4获得。
Developing novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challenge because of the poor water solubility, low reactive oxygen species (ROS) generation efficiency, serve dark cytotoxicity, and weak absorption in the NIR region of conventional photosensitizers. Herein, cyclometalated iridium (III) complexes (Ir) with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photon excitation, and mitochondria-targeting capability were designed and further encapsulated into biocompatible nanoparticles (NPs). The Ir-NPs can be used to disturb redox homeostasis in vitro, result in mitochondrial dysfunction and cell apoptosis. Importantly, in vivo experiments demonstrated that the Ir-NPs presented obviously tumor-targeting ability, excellent antitumor effect, and low systematic dark-toxicity. Moreover, the Ir-NPs could serve as a two-photon imaging agent for deep tissue bioimaging with a penetration depth of up to 300 μm. This work presents a promising strategy for designing a clinical application of multifunctional Ir-NPs toward bioimaging and PDT. The online version contains supplementary material available at 10.1186/s12951-021-01001-4.
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影响因子：
4.9
作者：
Park, So Young;Oh, Kyung Taek;Lee, Eun Seong
通讯作者：
Lee, Eun Seong
影响因子：
15
作者：
Kim, Sehoon;Ohulchanskyy, Tymish Y.;Prasad, Paras N.
通讯作者：
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影响因子：
15
作者：
VANHOUTEN, J;WATTS, RJ
通讯作者：
WATTS, RJ
DOI：
10.1073/pnas.1417253111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Jiang, Xian;Jiang, Hui;Wang, Xiaodong
通讯作者：
Wang, Xiaodong
影响因子：
14
作者：
Jiang, Lingyu;Zhou, Qing;Yang, Xiangliang
通讯作者：
Yang, Xiangliang