Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity
Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity
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橙皮苷通过抑制 Th17 活性来抑制 NC/Nga 小鼠特应性皮炎样皮肤病变的发展
DOI：
10.1016/j.jff.2013.07.005
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发表时间：
2013
期刊：
影响因子：
5.6
通讯作者：
Tanabe S.
中科院分区：
文献类型：
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作者：
Nagashio Y;Matsuura Y;Miyamoto J;Kometani T;Suzuki T;Tanabe S.
橙皮苷（以前称为维生素P）是柑橘类水果中主要的黄酮，由于其具有多种生理活性，因此被认为对人体健康有有益作用。在本研究中，我们研究了橙皮苷及其衍生物α-葡萄糖吡喃基(αG)-橙皮苷对人样异位性皮炎小鼠NC/Nga模型的抗过敏和抗炎作用。NC/Nga小鼠分别饲喂0.1% α - g -橙皮苷或橙皮苷日粮8周。α - g -橙皮苷和橙皮苷喂养均能有效抑制皮肤病变和免疫球蛋白E （IgE）升高。8周实验结束时，α g -橙皮苷/橙皮苷饲喂组脾细胞炎性细胞因子白细胞介素(IL)-17和干扰素γ (IFN-γ)的产生低于对照组。利用DNA微阵列和实时RT-PCR检测脾细胞mRNA表达的变化。结果表明，细胞毒性t淋巴细胞抗原4 (CTLA4)，一种调节性t细胞（Treg）标记物，在脾细胞中显著上调，特别是α g -橙皮苷饲喂后。这些结果表明，α g -橙皮苷可以减轻ad样症状的恶化，部分通过降低IgE、IL-17和IFN-γ来降低全身免疫高反应性，并调节NC/Nga小鼠的Th17/Treg平衡。因此，α g -橙皮苷可能有助于治疗th17介导的过敏性疾病。
Hesperidin (previously called vitamin P) is a predominant flavanone present in citrus fruits, and is presumed to have a role in their beneficial effect for human health because it possesses various physiological activities. In this study, we investigated the anti-allergic and anti-inflammatory effects of hesperidin and α-glucopyranosyl (αG)-hesperidin, its derivative with enhanced water-solubility, in NC/Nga mice, a human-like mouse model of atopic dermatitis. NC/Nga mice were fed a 0.1% αG-hesperidin or hesperidin diet for 8 weeks. αG-hesperidin and hesperidin feeding effectively inhibited skin lesions and immunoglobulin E (IgE) elevation. At the end of the 8-week-experimental period, the production of inflammatory cytokine interleukin (IL)-17 and interferon-gamma (IFN-γ) from splenocytes was lower in the αG-hesperidin/hesperidin-fed group than in the control group. Changes in mRNA expression in splenocytes are also examined using DNA microarray and real-time RT-PCR. It was revealed that cytotoxic T-lymphocyte antigen 4 (CTLA4), a regulatory T-cell (Treg) marker, was markedly upregulated in splenocytes, particularly by αG-hesperidin feeding. These results suggest that αG-hesperidin attenuated exacerbation of AD-like symptoms, decreased systemic immune hyper-responsiveness in part through the reduction of IgE, IL-17 and IFN-γ, and also modulated Th17/Treg balance in NC/Nga mice. Therefore, αG-hesperidin may be useful in the management of Th17-mediated allergic disorders.
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DOI：
10.1073/pnas.0500098102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Mohamadzadeh, M;Olson, S;Klaenhammer, TR
通讯作者：
Klaenhammer, TR
影响因子：
20.3
作者：
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影响因子：
14.2
作者：
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通讯作者：
J. Pestel
影响因子：
5.4
作者：
Tanabe, Soichi;Hochi, Satomi
通讯作者：
Hochi, Satomi
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