Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.
Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.
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DOI：
10.3389/fphys.2021.719680
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发表时间：
2021
影响因子：
4
通讯作者：
Tass PA
中科院分区：
文献类型：
--
作者：
Khaledi-Nasab A;Kromer JA;Tass PA
异常强烈的同步活动与几种神经系统疾病有关，包括特发性震颤、癫痫和帕金森病。慢性高频脑深部电刺激（HF DBS）是晚期帕金森病的一种既定治疗方法。为了减少递送的积分电流，新颖的基于理论的刺激技术（诸如协调复位（CR）刺激）通过经由多个刺激部位递送相移刺激来直接抵消异常同步激发。在具有尖峰定时依赖可塑性（STDP）的神经元网络的计算研究中，研究表明CR刺激下调突触权重，并将网络驱动到稳定去同步状态的吸引子中。这导致了持续时间超过刺激的去极化效应。在临床前和临床研究中观察到了相应的长效治疗效果。计算研究表明，CR刺激的持久效果取决于刺激频率对主导同步节律的调整。这可能限制临床适用性，因为不同的病理节律可能共存。为了增加持久效应的鲁棒性，我们研究了具有STDP的泄漏整合和激发神经元网络中的CR刺激的随机版本。随机化通过向刺激时间添加随机抖动并且通过打乱刺激部位激活的序列来获得。我们使用分析计算和计算机模拟来研究相应的长期影响。我们表明，随机抖动增加的鲁棒性的长期持久的影响，刺激部位的数量和刺激频率的变化。相比之下，洗牌不增加长期影响的参数稳健性。研究刺激的急性、急性后效应和长期效应之间的关系，我们发现，急性后效应和长期效应都强烈地取决于刺激诱导的突触重塑，而急性效应仅取决于所给予刺激的统计数据。我们发现，刺激持续时间是另一个重要的参数，因为有效的刺激只有在足够的刺激持续时间后才能产生持久的效果。我们的研究结果表明，具有随机抖动的CR刺激的长期治疗效果比常规CR刺激更稳健。这可能会减少未来临床试验中的参数调整时间，并使具有随机抖动的CR更适合于治疗多个频带中异常同步的脑部疾病。
Abnormally strong synchronized activity is related to several neurological disorders, including essential tremor, epilepsy, and Parkinson's disease. Chronic high-frequency deep brain stimulation (HF DBS) is an established treatment for advanced Parkinson's disease. To reduce the delivered integral electrical current, novel theory-based stimulation techniques such as coordinated reset (CR) stimulation directly counteract the abnormal synchronous firing by delivering phase-shifted stimuli through multiple stimulation sites. In computational studies in neuronal networks with spike-timing-dependent plasticity (STDP), it was shown that CR stimulation down-regulates synaptic weights and drives the network into an attractor of a stable desynchronized state. This led to desynchronization effects that outlasted the stimulation. Corresponding long-lasting therapeutic effects were observed in preclinical and clinical studies. Computational studies suggest that long-lasting effects of CR stimulation depend on the adjustment of the stimulation frequency to the dominant synchronous rhythm. This may limit clinical applicability as different pathological rhythms may coexist. To increase the robustness of the long-lasting effects, we study randomized versions of CR stimulation in networks of leaky integrate-and-fire neurons with STDP. Randomization is obtained by adding random jitters to the stimulation times and by shuffling the sequence of stimulation site activations. We study the corresponding long-lasting effects using analytical calculations and computer simulations. We show that random jitters increase the robustness of long-lasting effects with respect to changes of the number of stimulation sites and the stimulation frequency. In contrast, shuffling does not increase parameter robustness of long-lasting effects. Studying the relation between acute, acute after-, and long-lasting effects of stimulation, we find that both acute after- and long-lasting effects are strongly determined by the stimulation-induced synaptic reshaping, whereas acute effects solely depend on the statistics of administered stimuli. We find that the stimulation duration is another important parameter, as effective stimulation only entails long-lasting effects after a sufficient stimulation duration. Our results show that long-lasting therapeutic effects of CR stimulation with random jitters are more robust than those of regular CR stimulation. This might reduce the parameter adjustment time in future clinical trials and make CR with random jitters more suitable for treating brain disorders with abnormal synchronization in multiple frequency bands.
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影响因子：
5.3
作者：
Brocker DT;Swan BD;Turner DA;Gross RE;Tatter SB;Koop MM;Bronte-Stewart H;Grill WM
通讯作者：
Grill WM
影响因子：
8.6
作者：
Berner, Rico;Sawicki, Jakub;Schoell, Eckehard
通讯作者：
Schoell, Eckehard
影响因子：
3.2
作者：
Ebert M;Hauptmann C;Tass PA
通讯作者：
Tass PA
影响因子：
8.6
作者：
Adamchic, Ilya;Hauptmann, Christian;Barnikol, Utako Brigit;Pawelczyk, Norbert;Popovych, Oleksandr;Barnikol, Thomas Theo;Silchenko, Alexander;Volkmann, Jens;Deuschl, Guenter;Meissner, Wassilios G.;Maarouf, Mohammad;Sturm, Volker;Freund, Hans-Joachim;Tass, Peter Alexander
通讯作者：
Tass, Peter Alexander
影响因子：
5.3
作者：
Bi, GQ;Poo, MM
通讯作者：
Poo, MM