Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism.
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism.
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DOI：
10.1152/japplphysiol.00497.2022
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发表时间：
2023-03-01
影响因子：
3.3
通讯作者：
Leija, Robert G.
中科院分区：
文献类型：
--
作者：
Brooks, George A.;Osmond, Adam D.;Arevalo, Jose A.;Duong, Justin J.;Curl, Casey C.;Moreno-Santillan, Diana D.;Leija, Robert G.
不再被视为代谢废物和肌肉疲劳的原因，当代观点将乳酸盐在正常和病理生理条件下的代谢，传感和信号传导中的作用结合起来。乳酸盐以毫摩尔浓度存在于肌肉、血液和其他组织中，并且由于产量增加和清除限制，其浓度可以上升超过一个数量级。乳酸通过质量作用、氧化还原变化、变构结合和本文描述的其他机制发挥其强大的驱动剂样影响。根据条件，例如在休息和运动期间，在碳水化合物营养、损伤或病理学之后，乳酸可以作为具有自分泌、旁分泌和内分泌样功能的肌因子或运动因子，这些功能具有重要的基础和翻译意义。例如，乳酸信号是：参与生殖生物学，为心脏提供燃料，肌肉适应，大脑执行功能，生长和发育，以及炎症条件的治疗。乳酸盐还与许多其他机制和因素一起控制运动期间的心输出量和肺通气。具有讽刺意味的是，当乳酸转运蛋白插入胰腺β细胞膜不受抑制时，乳酸可能破坏正常过程，如胰岛素分泌，并且当抑制致癌作用的因子受到抑制而促进致癌作用的因子被上调时，乳酸可能破坏致癌作用。乳酸信号传导在中间代谢、氧化还原生物学、线粒体生物发生、神经生物学、肠道生理学、食欲调节、营养以及整体健康和活力领域中是重要的。乳酸作为肌因子和运动因子的各种作用进行了综述。新&值得注意的是乳酸传感和信号是一个相对较新且变化迅速的领域。乳酸作为一种生理信号，既独立地起作用，又与其他信号协同作用。乳酸盐通过共价结合和规范信号传导、氧化还原变化和DNA的乳酸化来起作用。乳酸盐也可以作为心肺调节中的反馈回路的元素。从受孕到衰老，乳酸并不是唯一的肌因子或运动因子，但它确实值得考虑作为一种生理信号。
No longer viewed as a metabolic waste product and cause of muscle fatigue, a contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in normal as well as pathophysiological conditions. Lactate exists in millimolar concentrations in muscle, blood, and other tissues and can rise more than an order of magnitude as the result of increased production and clearance limitations. Lactate exerts its powerful driver-like influence by mass action, redox change, allosteric binding, and other mechanisms described in this article. Depending on the condition, such as during rest and exercise, following carbohydrate nutrition, injury, or pathology, lactate can serve as a myokine or exerkine with autocrine-, paracrine-, and endocrine-like functions that have important basic and translational implications. For instance, lactate signaling is: involved in reproductive biology, fueling the heart, muscle adaptation, and brain executive function, growth and development, and a treatment for inflammatory conditions. Lactate also works with many other mechanisms and factors in controlling cardiac output and pulmonary ventilation during exercise. Ironically, lactate can be disruptive of normal processes such as insulin secretion when insertion of lactate transporters into pancreatic β-cell membranes is not suppressed, and in carcinogenesis when factors that suppress carcinogenesis are inhibited, whereas factors that promote carcinogenesis are upregulated. Lactate signaling is important in areas of intermediary metabolism, redox biology, mitochondrial biogenesis, neurobiology, gut physiology, appetite regulation, nutrition, and overall health and vigor. The various roles of lactate as a myokine and exerkine are reviewed. NEW & NOTEWORTHY Lactate sensing and signaling is a relatively new and rapidly changing field. As a physiological signal lactate works both independently and in concert with other signals. Lactate operates via covalent binding and canonical signaling, redox change, and lactylation of DNA. Lactate can also serve as an element of feedback loops in cardiopulmonary regulation. From conception through aging lactate is not the only a myokine or exerkine, but it certainly deserves consideration as a physiological signal.
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影响因子：
4.2
作者：
通讯作者：
--
DOI：
10.1016/s0305-0491(98)00025-x
发表时间：
1998-05-01
影响因子：
2.2
作者：
Brooks, GA
通讯作者：
Brooks, GA
影响因子：
3.3
作者：
Ali, MA;Yasui, F;Konishi, T
通讯作者：
Konishi, T
影响因子：
38.9
作者：
Bouzat, Pierre;Sala, Nathalie;Oddo, Mauro
通讯作者：
Oddo, Mauro
影响因子：
--
作者：
BARNARD, RJ;EDGERTON, VR;PETER, JB
通讯作者：
PETER, JB