Parvovirus B19-induced anemia as the presenting manifestation of X-linked hyper-IgM syndrome.
Parvovirus B19-induced anemia as the presenting manifestation of X-linked hyper-IgM syndrome.
复制标题
细小病毒 B19 诱导的贫血是 X 连锁高 IgM 综合征的表现。
DOI：
10.1086/515633
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Ochs,HD
中科院分区：
文献类型：
--
作者：
Seyama,K;Kobayashi,R;Hasle,H;Apter,AJ;Rutledge,JC;Rosen,D;Ochs,HD
细小病毒B19（B19）可导致慢性贫血，这是由于免疫功能低下的宿主持续感染而无法产生清除B19所需的中和抗体。3例X连锁高IgM综合征（XHIM）患者在8岁、14岁和17岁时均无症状，直到他们分别发生B19诱导的慢性贫血，发现CD40 L基因突变，包括错义突变（T254 M），导致新起始密码子和胞内结构域丢失的无义突变（R11 X），剪接位点突变（nt309 +2t→a）。对T细胞依赖性抗原噬菌体φX174的抗体应答受损，但中和抗体滴度高于经典表型的XHIM患者。所有3例患者均对静脉注射免疫球蛋白（IVIG）治疗有反应。CD40L基因的某些突变导致轻度XHIM表型，在未接受IVIG治疗的患者中B19感染后可能变得明显，因此不能保护免受B19感染。
Parvovirus B19 (B19) can cause chronic anemia due to persistent infection in immunocompromised hosts who cannot produce neutralizing antibody necessary for clearing B19. Three patients with X-linked hyper-IgM syndrome (XHIM), who were all asymptomatic until they developed B19-induced chronic anemia at the ages of 8, 14, and 17 years, respectively, were found to have mutations of theCD40Lgene, including a missense mutation (T254M), a nonsense mutation resulting in a new initiation codon and loss of the intracellular domain (R11X), and a splice site mutation (nt 309+2t→a). Antibody responses to the T cell-dependent antigen, bacteriophage φX174, were impaired, but neutralizing antibody titers were higher than in XHIM patients with classic phenotype. All 3 patients responded to intravenous immune globulin (IVIG) treatment. Certain mutations of theCD40Lgene result in a mild XHIM phenotype that may become apparent following B19 infection in patients not on IVIG therapy and therefore not protected from B19 infection.
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人类细小病毒关节病
DOI：
--
发表时间：
1985
期刊：
The Lancet
影响因子：
--
作者：
D. White;D. White;P. Mortimer;P. Mortimer;D. Blake;D. Blake;A. D. Woolf;A. D. Woolf;B. Cohen;B. Cohen;P. Bacon;P. Bacon
通讯作者：
P. Bacon
影响因子：
4.4
作者：
A. Hayward;J. Levy;F. Facchetti;L. Notarangelo;H. Ochs;Amos Etzioni;J. Bonnefoy;M. Cosyns;A. Weinberg
通讯作者：
A. Hayward;J. Levy;F. Facchetti;L. Notarangelo;H. Ochs;Amos Etzioni;J. Bonnefoy;M. Cosyns;A. Weinberg
人类抗体对噬菌体 phi X 174 的反应：连续诱导 IgM 和 IgG 亚类抗体。
DOI：
10.1016/0090-1229(89)90024-x
发表时间：
1989
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Pyun,KH;Ochs,HD;Wedgwood,RJ;Yang,XQ;Heller,SR;Reimer,CB
通讯作者：
Reimer,CB
影响因子：
64.8
作者：
MORTIMER, PP;HUMPHRIES, RK;YOUNG, NS
通讯作者：
YOUNG, NS
影响因子：
5.7
作者：
KARPUSAS, M;HSU, YM;THOMAS, D
通讯作者：
THOMAS, D