Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
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DOI：
10.1371/journal.pone.0129950
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Sakaida I
中科院分区：
文献类型：
--
作者：
Fujisawa K;Terai S;Matsumoto T;Takami T;Yamamoto N;Nishina H;Furutani-Seiki M;Sakaida I
Maid是一种螺旋-环-螺旋蛋白，参与细胞增殖。为了进一步阐明其生理功能，我们在两个小型鱼类模型系统中研究了Maid活性。我们发现Maid在斑马鱼肝脏中的表达最高，并且在部分肝切除术后表达增加。女仆水平也很高，在肝肿瘤前病灶诱导治疗斑马鱼与二乙基亚硝胺（DEN），但低的肝细胞癌（HCC），混合瘤，胆管癌在这些动物的发展。在DEN处理的转基因青鳉过度表达女仆，肝BrdU摄取和增殖减少。在连续短缩后，Maid转基因青鳉表现出运动减少和更高的异常脊柱弯曲的发生率，可能是由于脊髓细胞的衰老。总之，我们的研究结果表明，女仆水平可以影响肝癌的进展。因此，我们发现，Maid是肝脏成癌和衰老的重要调节因子。
Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging.
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影响因子：
8
作者：
Chang, T-W;Chen, C-C;Chang, M-C
通讯作者：
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影响因子：
1.5
作者：
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影响因子：
13.5
作者：
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影响因子：
13.5
作者：
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通讯作者：
Thorgeirsson, SS
DOI：
10.1016/j.cbpb.2009.01.006
发表时间：
2009-05-01
影响因子：
2.2
作者：
Fujisawa, Koichi;Murakami, Ryutaro;Noma, Takafumi
通讯作者：
Noma, Takafumi