Estimation of Observer Performance for Reduced Radiation Dose Levels in CT: Eliminating Reduced Dose Levels That Are Too Low Is the First Step.
Estimation of Observer Performance for Reduced Radiation Dose Levels in CT: Eliminating Reduced Dose Levels That Are Too Low Is the First Step.
复制标题
CT中降低辐射剂量水平的观察者性能的估计：消除过低剂量水平的降低是第一步。
DOI：
10.1016/j.acra.2016.12.017
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发表时间：
2017-07
影响因子：
4.8
通讯作者：
McCollough CH
中科院分区：
文献类型：
--
作者：
Fletcher JG;Yu L;Fidler JL;Levin DL;DeLone DR;Hough DM;Takahashi N;Venkatesh SK;Sykes AG;White D;Lindell RM;Kotsenas AL;Campeau NG;Lehman VT;Bartley AC;Leng S;Holmes DR 3rd;Toledano AY;Carter RE;McCollough CH
评估常见CT检查的一系列剂量水平的观察者表现(检测肝转移或肺结节，以及神经功能缺失的原因)，以便确定用于进一步分析的非劣质剂量水平的优先顺序。利用131例CT(腹部CT 44例，胸部CT 44例，头部CT 43例)的CT数据，采用滤波反投影(FBP)或迭代重建(IR)的方法对常规临床剂量的4~100%的CT图像进行重建。放射科医生评估CT图像，标记指定的靶点，提供置信度分数，并对图像质量进行评级。使用参考标准、读者协议规则和jacknife替代自由反应接收器工作特性(JAFROC)品质因数(FOM)来评估非劣等性。阅读器协议要求大多数较低剂量的阅读器识别大多数阅读器在常规剂量下看到的靶病变。读者协议指出，低于50%和4%的剂量水平分别对肝转移瘤和肺结节的检测效果不佳，但不能排除头部CT的任何低剂量水平。JAFROC FOM在常规剂量配置和较低剂量配置之间的估计差异发现，只有测试的最低剂量配置(即腹部、胸部和头部CT的常规剂量水平的30%、4%和10%)不符合非劣质标准。在较低剂量下，主观图像质量在观察者表现之前下降。只有当FBP不会导致非劣质表现时，IR才是有益的。利用现有的CT技术进行常见的诊断任务，有机会大幅减少辐射剂量。
To estimate observer performance for a range of dose levels for common CT exams (detection of liver metastases or pulmonary nodules, and cause of neurologic deficit) in order to prioritize non-inferior dose levels for further analysis. Using CT data from 131 exams (44 abdominal CT, 44 chest CT, 43 head CT), CT images corresponding to 4 – 100% of routine clinical dose were reconstructed with filtered back projection (FBP) or iterative reconstruction (IR). Radiologists evaluated CT images, marking specified targets, providing confidence scores, and grading image quality. Non-inferiority was assessed using reference standards, reader agreement rules and jacknife alternative free-response receiver operating characteristic (JAFROC) figure of merit (FOM). Reader agreement required that a majority of readers at lower dose identify target lesions seen by the majority of readers at routine dose. Reader agreement identified dose levels lower than 50% and 4% to have inadequate performance for detection of hepatic metastases and pulmonary nodules respectively, but could not exclude any low dose levels for head CT. Estimated differences in JAFROC FOM between routine and lower dose configurations found that only the lowest dose configurations tested (i.e., 30%, 4% and 10% of routine dose levels for abdominal, chest and head CT, respectively) did not meet criteria for non-inferiority. At lower doses, subjective image quality declined before observer performance. IR was only beneficial when FBP did not result in non-inferior performance. Opportunity exists for substantial radiation dose reduction using existing CT technology for common diagnostic tasks.
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影响因子：
19.7
作者：
Goenka, Ajit H.;Herts, Brian R.;Baker, Mark E.
通讯作者：
Baker, Mark E.
影响因子：
3.5
作者：
Gabriel, S.;Eckel, L. J.;Yu, L.
通讯作者：
Yu, L.
影响因子：
3.5
作者：
Korn, A.;Fenchel, M.;Brodoefel, H.
通讯作者：
Brodoefel, H.
影响因子：
19.7
作者：
Pontana, Francois;Billard, Anne-Sophie;Remy-Jardin, Martine
通讯作者：
Remy-Jardin, Martine
DOI：
10.2214/ajr.09.2754
发表时间：
2009-07
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
McCollough CH;Guimarães L;Fletcher JG
通讯作者：
Fletcher JG