DRYGIN: a database of quantitative genetic interaction networks in yeast.

DRYGIN: a database of quantitative genetic interaction networks in yeast.
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DOI:
10.1093/nar/gkp820
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发表时间:
2010-01
影响因子:
14.9
通讯作者:
Boone C
Boone C
中科院分区:
生物学2区
文献类型:
--
作者:
Koh JL;Ding H;Costanzo M;Baryshnikova A;Toufighi K;Bader GD;Myers CL;Andrews BJ;Boone C

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遗传相互作用对于解释基因如何控制细胞过程的基本功能原则具有重要意义。合成遗传阵列(SGA)分析的最新发展使得在全基因组范围内绘制定量遗传相互作用成为可能。为了方便访问这一资源,这将最终代表一个完整的遗传相互作用网络的真核细胞,我们开发了DRYGIN(酵母遗传相互作用的数据库)-一个网络数据库系统,旨在提供一个中央平台,酵母遗传网络分析和可视化。DRYGIN除了提供用于搜索SGA遗传相互作用的接口外,还集成了其他数据源,以便将遗传相互作用与途径信息、蛋白质复合物、其他二元遗传和物理相互作用以及Gene Ontology功能注释相关联。DRYGIN 1.0版目前拥有超过540万个涉及104500个基因的遗传相互作用对的测量结果,可在http://drygin.ccbr.utoronto.ca上获得
Genetic interactions are highly informative for deciphering the underlying functional principles that govern how genes control cell processes. Recent developments in Synthetic Genetic Array (SGA) analysis enable the mapping of quantitative genetic interactions on a genome-wide scale. To facilitate access to this resource, which will ultimately represent a complete genetic interaction network for a eukaryotic cell, we developed DRYGIN (Data Repository of Yeast Genetic Interactions)—a web database system that aims at providing a central platform for yeast genetic network analysis and visualization. In addition to providing an interface for searching the SGA genetic interactions, DRYGIN also integrates other data sources, in order to associate the genetic interactions with pathway information, protein complexes, other binary genetic and physical interactions, and Gene Ontology functional annotation. DRYGIN version 1.0 currently holds more than 5.4 million measurements of genetic interacting pairs involving ∼4500 genes, and is available at http://drygin.ccbr.utoronto.ca
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