Alcoholic hepatitis: Translational approaches to develop targeted therapies.
Alcoholic hepatitis: Translational approaches to develop targeted therapies.
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DOI：
10.1002/hep.28530
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发表时间：
2016-10
期刊：
影响因子：
13.5
通讯作者：
Gao, Bin
中科院分区：
文献类型：
--
作者：
Mandrekar, Pranoti;Bataller, Ramon;Tsukamoto, Hidekazu;Gao, Bin
酒精性肝病（ALD）是世界范围内肝脏相关死亡的主要原因。与病毒性肝炎患者治疗策略的最新进展相反，ALD患者明显缺乏新的治疗选择。特别是，迫切需要将我们的努力集中在酒精性肝炎（AH）的有效治疗干预上，这是ALD最严重的形式。AH的特点是大量饮酒患者突然出现黄疸和肝功能不全及门静脉高压症相关并发症。AH患者的死亡率非常高（3个月时为20-50%）。现有的治疗方法对许多患者无效，迫切需要有针对性的方法。这种疗法的发展需要在人类样本和合适的动物模型中进行转译研究，以再现AH的临床和组织学特征。近年来，新的动物模型模拟了人类AH的一些特征，使用人类样本的转化研究已经确定了潜在的致病因素和预测生存的组织学参数。本文综述了关于AH发病机制的转化研究、临床前转化工具以及使AH患者受益的新兴药物靶点等尚未满足的需求。
Alcoholic liver disease (ALD) is a leading cause of liver related mortality worldwide. In contrast to recent advances in therapeutic strategies for patients with viral hepatitis, there is a significant lack of novel therapeutic options for patients with ALD. In particular, there is an urgent need to focus our efforts on effective therapeutic interventions for alcoholic hepatitis (AH), the most severe form of ALD. AH is characterized by an abrupt development of jaundice and complications related to liver insufficiency and portal hypertension in patients with heavy alcohol intake. The mortality of patients with AH is very high (20–50% at 3 months). Available therapies are not effective in many patients and targeted approaches are imminently needed. The development of such therapies requires translational studies in human samples and suitable animal models that reproduce clinical and histological features of AH. In recent years, new animal models that simulate some of the features of human AH have been developed, and translational studies using human samples have identified potential pathogenic factors and histological parameters that predict survival. This review article summarizes the unmet needs for translational studies on the pathogenesis of AH, pre-clinical translational tools, and emerging drug targets to benefit the AH patient.
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影响因子：
29.4
作者：
Chen P;Torralba M;Tan J;Embree M;Zengler K;Stärkel P;van Pijkeren JP;DePew J;Loomba R;Ho SB;Bajaj JS;Mutlu EA;Keshavarzian A;Tsukamoto H;Nelson KE;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
6.1
作者：
DILUZIO, NR
通讯作者：
DILUZIO, NR
影响因子：
12.6
作者：
Altamirano, Jose;Fagundes, Claudia;Bataller, Ramon
通讯作者：
Bataller, Ramon
DOI：
10.1016/j.clinre.2015.05.008
发表时间：
2015-09
影响因子：
2.7
作者：
Gao B;Shah VH
通讯作者：
Shah VH
影响因子：
25.7
作者：
Lanthier, Nicolas;Rubbia-Brandt, Laura;Spahr, Laurent
通讯作者：
Spahr, Laurent