Upper-limb muscle responses to epidural, subdural and intraspinal stimulation of the cervical spinal cord.
Upper-limb muscle responses to epidural, subdural and intraspinal stimulation of the cervical spinal cord.
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DOI：
10.1088/1741-2560/11/1/016005
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发表时间：
2014-02
影响因子：
4
通讯作者：
Jackson A
中科院分区：
文献类型：
--
作者：
Sharpe AN;Jackson A
脊髓的电刺激在脊髓损伤后具有潜在的应用，用于使瘫痪的肢体复活并促进神经可塑性变化，这可能有助于运动康复。在这里，我们系统地比较了不同的刺激方法在麻醉猴的宫颈扩张的有效性，选择性和频率依赖性。刺激电极被定位在背侧和腹侧表面上的多个硬膜外和硬膜下部位，以及脊髓内的不同深度。记录手臂、前臂和手部肌肉的运动反应。从背侧到腹侧刺激部位的刺激有效性增加，腹侧硬膜外电极除外，其具有最高的募集阈值。与硬膜外和椎管内方法相比，硬膜下刺激的反应更具选择性，但相邻部位之间也更相似。列车的腹侧网站的刺激引起一致的反应，在所有的频率，而从背侧网站，我们观察到的混合物的短潜伏期的促进和长潜伏期的抑制。最后，成对的刺激传递到背表面和脊柱内的网站表现出对称的易化相互作用，在刺激间隔2-5毫秒之间，而在腹侧的相互作用往往是抑制近同时刺激。我们解释这些结果的上下文中的差异激活的传入和传出神经根和椎管内电路元件。特别是，我们提出，不同的直接和间接的动作脊髓刺激运动神经元可能有利于不同的应用程序，这应该考虑到设计神经假肢上肢功能。
Electrical stimulation of the spinal cord has potential applications following spinal cord injury for reanimating paralysed limbs and promoting neuroplastic changes that may facilitate motor rehabilitation. Here we systematically compare the efficacy, selectivity and frequency-dependence of different stimulation methods in the cervical enlargement of anaesthetized monkeys. Stimulating electrodes were positioned at multiple epidural and subdural sites on both dorsal and ventral surfaces, as well as at different depths within the spinal cord. Motor responses were recorded from arm, forearm and hand muscles. Stimulation efficacy increased from dorsal to ventral stimulation sites, with the exception of ventral epidural electrodes which had the highest recruitment thresholds. Compared to epidural and intraspinal methods, responses to subdural stimulation were more selective but also more similar between adjacent sites. Trains of stimuli delivered to ventral sites elicited consistent responses at all frequencies whereas from dorsal sites we observed a mixture of short-latency facilitation and long-latency suppression. Finally, paired stimuli delivered to dorsal surface and intraspinal sites exhibited symmetric facilitatory interactions at interstimulus intervals between 2–5 ms whereas on the ventral side interactions tended to be suppressive for near-simultaneous stimuli. We interpret these results in the context of differential activation of afferent and efferent roots and intraspinal circuit elements. In particular, we propose that distinct direct and indirect actions of spinal cord stimulation on motoneurons may be advantageous for different applications, and this should be taken into consideration when designing neuroprostheses for upper-limb function.
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影响因子：
4
作者：
Kasten MR;Sunshine MD;Secrist ES;Horner PJ;Moritz CT
通讯作者：
Moritz CT
DOI：
10.1109/tnsre.2003.823268
发表时间：
2004-03-01
影响因子：
4.9
作者：
Aoyagi, Y;Mushahwar, VK;Prochazka, A
通讯作者：
Prochazka, A
影响因子：
5.5
作者：
Jackson, A.;Baker, S. N.;Fetz, E. E.
通讯作者：
Fetz, E. E.
影响因子：
2.5
作者：
Perlmutter, SI;Maier, MA;Fetz, EE
通讯作者：
Fetz, EE
影响因子：
4
作者：
Normann RA;Dowden BR;Frankel MA;Wilder AM;Hiatt SD;Ledbetter NM;Warren DA;Clark GA
通讯作者：
Clark GA