Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage.
Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage.
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C57BL/6J 和 DBA/2J 谱系小鼠后肢肌肉组织变异的基因组分析。
DOI：
10.1093/jhered/esq023
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Blizard,DavidA
中科院分区：
文献类型：
--
作者：
Lionikas,Arimantas;Carlborg,Orjan;Lu,Lu;Peirce,JeremyL;Williams,RobertW;Yu,Fushun;Vogler,GeorgeP;McClearn,GeraldE;Blizard,DavidA
肌肉与骨骼连接点的准确位置--起始点和起始点--是影响运动能力的关键解剖学和功能特征。控制肌肉、肌腱和骨骼之间这些相互作用发展的机制目前还不是很清楚。在来自C57BL/6J和DBA/2J品系的BXD重组近交系(RI)品系中，我们观察到比目鱼肌股骨附着异常(SFAA)，这在两个亲本品系中都是罕见的(Lionikas，Glover等)。2006)。本研究的目的是评估SFAA作为研究肌肉骨骼解剖变异的遗传机制的模型的适宜性。我们对55个BXD菌株的SFAA发病率进行了评分(n=9至136，中位数=26，每个菌株的表型动物总数为2367只)。7株(Bxd1、12、38、43、48、54和56株)单侧SFAA的发生率较高(47-%)，而23株SFAA的发生率为0。对Bxd1和BXD38两个高发菌株SFAA发生机制的研究表明，SFAA相关基因存在于Bxd1基因组的C57BL/6J和DBA/2J区域。然而，并不是所有与表型表达相关的等位基因在两个BXD高发株之间都是相同的。结论：小鼠比目鱼肌的解剖起源是由多基因系统控制的。一组BXD RI菌株是探索SFAA背后的遗传机制和提高我们对肌肉骨骼发育的理解的有用工具。
The precise locations of attachment points of muscle to bone—the origin and insertion sites—are crucial anatomical and functional characteristics that influence locomotor performance. Mechanisms that control the development of these interactions between muscle, tendon, and bone are currently not well understood. In a subset of BXD recombinant inbred (RI) strains derived from the C57BL/6J and DBA/2J strains, we observed a soleus femoral attachment anomaly (SFAA) that was rare in both parental strains (Lionikas, Glover et al. 2006). The aim of the present study was to assess suitability of SFAA as a model to study the genetic mechanisms underlying variation in musculoskeletal anatomy. We scored the incidence of SFAA in 55 BXD strains (n= 9 to 136, median = 26, phenotyped animals per strain, for a total number of 2367). Seven strains (BXD1, 12, 38, 43, 48, 54, and 56) exhibited a high incidence of unilateral SFAA (47–89%), whereas 23 strains scored 0%. Exploration of the mechanisms underlying SFAA in 2 high incidence strains, BXD1 and BXD38, indicated that SFAA-relevant genes are to be found in both C57BL/6J and DBA/2J regions of the BXD1 genome. However, not all alleles relevant for the expression of the phenotype were shared between the 2 high-incidence BXD strains. In conclusion, the anatomical origin of the soleus muscle in mouse is controlled by a polygenic system. A panel of BXD RI strains is a useful tool in exploring the genetic mechanisms underlying SFAA and improving our understanding of musculoskeletal development.
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影响因子：
4
作者：
Hanh T. Nguyen;M. Frasch
通讯作者：
Hanh T. Nguyen;M. Frasch
人类比目鱼肌异常延伸的腓骨起源：基于比较解剖学的可能的形态生理意义
影响因子：
2.4
作者：
F. Barberini;C. Bucciarelli;A. Zani;D. Cerasoli
通讯作者：
D. Cerasoli
鸟类后肢的肌肉和肌腱形态发生。
DOI：
10.1242/dev.125.20.4019
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Kardon,G
通讯作者：
Kardon,G
DOI：
10.1111/j.1600-0838.1995.tb00030.x
发表时间：
1995
影响因子：
4.1
作者：
I. Ekenman;L. Tsai;C. Johansson;M. O'Brien
通讯作者：
M. O'Brien