Quantitative trait loci for lifespan of mated Drosophila melanogaster affect both sexes.

Quantitative trait loci for lifespan of mated Drosophila melanogaster affect both sexes.
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交配果蝇寿命的数量性状基因座影响两性。

DOI:
10.1017/s0016672302005943
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发表时间:
2002
期刊:
Genetical research
影响因子:
--
通讯作者:
Nuzhdin,SergeyV
Nuzhdin,SergeyV
中科院分区:
--
文献类型:
--
作者:
Reiwitch,SarahG;Nuzhdin,SergeyV

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为了确定寿命的进化机制和预测寿命的未来变化,必须描述导致寿命变化的数量性状基因座(QTL)上的等位基因的特性。此前,我们和其他人使用密集的分子标记图谱对分离于一组重组自交系(RIL)中的QTL进行了全基因组筛选。在无压力条件下,影响处女女性和男性寿命的QTL通常是性别特有的。在一组不相关的RIL中,QTL对饲养在混合性别笼子中的果蝇的影响在性别上是相似的。在这里,我们重新测量了前一组在笼子里混杂性别的RIL的寿命。由于交配,寿命下降。品系内不同性别间的下降幅度相关。位于15A-19C、50B-57C、63A-65A和96F-99B区间的QTL对雌雄寿命的影响相似。这些QTL以前在处女苍蝇调查中被检测到,并具有性别和/或环境特有的影响。
The properties of alleles at quantitative trait loci (QTLs) contributing to variation in lifespan should be described to determine the mechanisms of evolution of life length and to predict its future changes. Previously, we and others conducted genome-wide screens for QTLs that segregate among one panel of recombinant inbred lines (RILs) using a dense molecular marker map. In non-stressful conditions, QTLs effecting the lifespans of virgin females and males were frequently sex specific. In an unrelated panel of RILs, the effects of QTLs in flies maintained in cages with mixed sexes were similar in both sexes. Here, we re-measured the lifespans of the former panel of RILs in cages with mixed sex cohorts. Lifespan declined owing to mating. The amount of decline correlated between sexes within lines. QTLs mapping to the intervals 15A–19C, 50B–57C, 63A–65A, and 96F–99B had similar effects on the lifespans of both males and females. These QTLs have previously been detected in virgin flies surveys and had sex- and/or environment-specific effects.
DOI: 10.1001/jama.1985.03350440053030
发表时间: 1985
期刊: JAMA
影响因子: --
作者:
P. Remington;M. Forman;E. Gentry;J. Marks;G. Hogelin;F. Trowbridge
通讯作者: F. Trowbridge
香烟尼古丁含量会影响抽吸量吗?
DOI: 10.1038/clpt.1982.182
发表时间: 1982
影响因子: 6.7
作者:
Gust,SW;Pickens,RW
通讯作者: Pickens,RW
DOI: --
发表时间: 1985
期刊: Journal of the American Medical Association (JAMA)
影响因子: --
作者:
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通讯作者: J. Buring
DOI: 10.1056/nejm198302243080801
发表时间: 1983-01-01
影响因子: 158.5
作者:
KAUFMAN, DW;HELMRICH, SP;SHAPIRO, S
通讯作者: SHAPIRO, S
DOI: 10.1056/nejm198512123132404
发表时间: 1985-01-01
影响因子: 158.5
作者:
ROSENBERG, L;KAUFMAN, DW;SHAPIRO, S
通讯作者: SHAPIRO, S